Abstract: Objective To explore the diagnosis,treatment and prognosis of the optic nerve glioma.Methods Sixteen cases with optic nerve glioma from 2003 to 2007 were collected and their clinical manifestations were summarized and analyzed.Results There were 9 females and 7 males;aged 2～53;8 right side,4 left side,4 bilateral;decline of visual acuity noted in 15;defects of visual field in 12;changes in ocular fundus in 7;headache in 4;ophthalmalgia in 2;exophthalmus in 1;intracranial hypertension in 2;sexual precocity in 1.All cases had positive results in CT and MRI.All cases had undergone operation.Three had postoperative irradiation.Eight cases resulted in blindness,death in 1 and decline of visual acuity in 7.Pathologic diagnosis:astrocytoma of optic nerve in 14,glioblastoma of optic nerve in 1,without pathologic diagnosis in 1.Conclusion Optic nerve glioma is often seen in children under 10,it is usually benign and self-limited.When occurs in adults,it is often malignant.It can cause varied symptoms and signs in eyes and intracranial complications.Comprehensive therapeutic methods should be adopted,including operation,radiotherapy and chemotherapy,etc.Prognosis is dependent on the range involved and the nature of the tumor.

Key words: optic nerve glioma, diagnosis, therapy, prognosis