The Biologic Significance of Wnt Signaling Pathway in Lung Disease

Abstract

Abstract:

The Wnt signaling pathway is a highly conserved signaling pathway. It mainly consists of the canonical Wnt/β-catenin pathway and the non-canonical pathway〔the Wnt/planar cell polarity(PCP) pathway and the Wnt/Ca²⁺ pathway〕. Wnt pathway is involved in a wide range of biological functions, such as cell adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence have suggested that the activation of Wnt signaling pathway is substantially involved in the pathogenesis of several pulmonary diseases, such as idiopathic pulmonary arterial hypertension, asthma, idiopathic pulmonary fibrosis and lung cancer. This review focuses on the biological significance of Wnt signaling pathway in lung diseases.

Key words: Wnt signaling, pulmonary arterial hypertension, asthma, idiopathic pulmonary fibrosis, lung cancer

CLC Number:

R 563
R 332

YU Xiao-min;;WANG Chen;WANG Jun. The Biologic Significance of Wnt Signaling Pathway in Lung Disease[J]. Journal of Capital Medical University, 2009, 30(2): 182-184.

[1]	Li Tiezheng, Xu Kaikai, Deng Yuqing, Wang Peihao, Qin Qi, Guo Kangshun, Wang Bingren, Chang Dong, Cui Yong. Analysis of the efficacy and safety of PD-1 inhibitors combined with chemotherapy in neoadjuvant treatment of locally advanced non-small cell lung cancer [J]. Journal of Capital Medical University, 2024, 45(4): 636-641.
[2]	Wu Zhaozhen, Zheng Hua, Sheng Shuyan, Zhang Quan, Zhang Hui, Li Jie, Lyu Jialin, Qian Zhe, Wang Shouzheng, Li Xi , Hu Ying. Observation on the preliminary efficacy of neoadjuvant immunotherapy combined with chemotherapy in non-small cell lung cancer [J]. Journal of Capital Medical University, 2024, 45(4): 642-648.
[3]	Xu Yuan, Liang Naixin, Liu Hongsheng. Prognostic factors in neoadjuvant immunotherapy for non-small cell lung cancer：pathologic lymph node metastasis and primary tumor response [J]. Journal of Capital Medical University, 2024, 45(4): 649-653.
[4]	Wang Jusi, Song Weian, Di Shouyin, Liu Junqiang, Fan Boshi, Zhou Shaohua, Yue Caiying, Zhao Jiahua, Chen Siyu, Gong Taiqian. Efficacy of neoadjuvant chemotherapy combined with immunotherapy in the treatment of stage Ⅲ non-small cell lung cancer [J]. Journal of Capital Medical University, 2024, 45(4): 660-665.
[5]	Hao Zhuohong, Yun Duo, Zhang Ying, Li Huihui, Lin Haishan, Cui Yong, Zhao Lei. Advances in research of perioperative immunotherapy for non-small cell lung cancer—advances in neoadjuvant immunotherapy [J]. Journal of Capital Medical University, 2024, 45(4): 666-677.
[6]	Wang Ming, Hong Yu, Bu Xiangting, Wang Chengshuo, Zhang Luo. Dysregulation of genes related to fibrin formation and degradation in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps [J]. Journal of Capital Medical University, 2024, 45(2): 246-251.
[7]	Tian Xiaoru, Qian Kun, Zhang Peilong, Zhang Yi. Analysis of risk factors for postoperative complications after uniportal-VATS lobectomy or segmentectomy in elderly patients with lung cancer [J]. Journal of Capital Medical University, 2024, 45(1): 118-126.
[8]	Luo Yi, Qin Qi, Wang Peihao, Guo Kangshun, Zhang Xinping, Cui Yong. Application and research progress of artificial intelligence combined with spectral diagnosis technology in the identification of lung cancer tissues [J]. Journal of Capital Medical University, 2023, 44(6): 1095-1102.
[9]	Peng Dan, Pang Jie, Shi Yifan, Cui Lele, Xu Yingjie, Li Yan, Cui Ye, Chen Yan, Yuan Huihui, Qin Xiaofeng, Lyu Zhe, Wang Wei, Sun Ying. Streptococcus pneumoniae infection at early stage of life affect the severity of asthma induced by exposure to the same bacterial antigens in adulthood [J]. Journal of Capital Medical University, 2023, 44(2): 212-220.
[10]	Yang Min, Yan Xiang, Liu Xijuan, An Guo, Ding Huirong, Cai Ying, Ge Huizheng. Establishment and characterization of immune cells in an orthotopic cell-derived xenograft mouse model of human lung cancer using multi-color flow cytometry [J]. Journal of Capital Medical University, 2023, 44(1): 99-106.
[11]	Li Yan, Wang Qiqi, Zhang Yuling, Duan Su, Zhang Haibo, Wang Xiangdong, Lan Feng. Clinical characteristics of chronic rhinosinusitis with nasal polyps with different body mass index [J]. Journal of Capital Medical University, 2022, 43(6): 899-904.
[12]	Li Ang, Huang Huijie, Yang Shiqing, Hou Xiaoling, Xiang Li. Analysis of characteristics of lung function trajectory in long-term treatment and management of children with asthma [J]. Journal of Capital Medical University, 2022, 43(6): 940-947.
[13]	Zhang Jingtao, Wang Xinran, Han Binru, Qiang Ying, Liu Xueqi, Zhang Yi. Analysis of clinical characteristics and risk factors of arrhythmia after thoracoscopic pneumonectomy in elderly patients with lung cancer [J]. Journal of Capital Medical University, 2022, 43(4): 564-569.
[14]	Xia Ning, Nie Xiuhong, Wang Hao, Fan Xiaojun. Association of OSA and asthma with the incidence rate of coronary heart disease [J]. Journal of Capital Medical University, 2022, 43(1): 138-142.
[15]	Tan Xiaogang, Zhang Yi. Progress in neoadjuvant immunotherapy for resectable non-small cell lung cancer [J]. Journal of Capital Medical University, 2021, 42(5): 862-867.

The Biologic Significance of Wnt Signaling Pathway in Lung Disease

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments