Rhythmic Oscillation of Neurotransmitter-related Genes Expression in the Mouse Striatum

doi:10.3969/j.issn.1006-7795.2009.05.002

Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (5): 580-583.doi: 10.3969/j.issn.1006-7795.2009.05.002

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Rhythmic Oscillation of Neurotransmitter-related Genes Expression in the Mouse Striatum

DING Hui¹, CAI Yan-ning¹, WANG Ling-ling², CHAI Yu-xin¹, ZHANG Yan-li¹, CHEN Biao¹

1. Department of Neurology and Neurobiology, Xuanwu Hospital, Capital Medical University; Key Laboratory of Neurodegenerative Diseases, Ministry of Education;2. Department of Neurology, Jimo People's Hospital, Shandong Province

Received:2009-07-16 Revised:1900-01-01 Online:2009-10-21 Published:2009-10-21

Abstract

Abstract: Objective The aims of this study were to determine whether striatal neuropeptides(dynorphin(DYN), enkephalin 1(ENK1), substance P(SP), cholecystokinin(CCK)) and dopamine receptor 1 and 2(D1r and D2r) are regulated by the molecular clock; whether their rhythmic changes depend on the matural molecular clock. Methods Twenty-four hour mRNA oscillations of these genes were evaluated in the mouse striatum at early postnatal(postnatal day 3), pre-weaning(postnatal day 14), and adult(postnatal day 60) stages. At P3, no daily oscillations were observed. Results A significant time effect was present for D2r, DYN, and ENK1 at P14, and for all genes except D1r, at P60. Conclusion Circadian expression of these neurotransmitter-related genes develops in the mouse striatum gradually.

Key words: striatum, neuropeptide, circadian rhythm, gene expression

CLC Number:

Q 344⁺.1

DING Hui;CAI Yan-ning;WANG Ling-ling;CHAI Yu-xin;ZHANG Yan-li;CHEN Biao. Rhythmic Oscillation of Neurotransmitter-related Genes Expression in the Mouse Striatum[J]. Journal of Capital Medical University, 2009, 30(5): 580-583.

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Rhythmic Oscillation of Neurotransmitter-related Genes Expression in the Mouse Striatum

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