Abstract: Objective To investigate the effect of smoking and drinking alcohol on esophageal mucosal low-grade neoplasia in Wu'an city. Methods A 1: 4 age-matched casecontrol study was conducted and questionnaire survey was used to obtain information, then Logistic regression and stratified analysis were applied to calculate odds radio and 95% confidence interval. Results Smoking was the risk factor of esophageal mucosal low-grade neoplasia, OR value was 2.282〔95% CI, 1.164-4.471］, P<0.05. Further stratified analysis of smoking group showed that the risk of smoking 1 to 10 cigarettes per day suffering from esophageal mucosal low-grade neoplasia was 3.450 times higher than that of non-smokers, whereas for those who smoked more than 11 cigarettes daily, the risk increased to 4.025 times that of nonsmokers. Smoking and esophageal mucosal low-grade neoplasia was correlated in a dose dependent manner. Drinking alcohol was not the risk factor of esophageal mucosal low-grade neoplasia. Conclusion In Wu'an esophageal cancer high incidence area, smoking was the risk factor of esophageal mucosal low-grade neoplasia, and had positive dose response relationship.

Key words: esophageal mucosal low grade neoplasia, smoking, drinking, casecontrol study