Abstract: Objective To study the relationship between carotid-femoral pulse wave velocity(C-F PWV) and severity of coronary artery disease(CAD),evaluate the usefulness of C-F PWV to predict the extent of coronary atherosclerosis lesions.Methods A total of 126 patients with suspected CAD were selected.C-F PWV was measured using an automatic device(Complior SP,France).The severity of coronary artery disease was evaluated by the number of diseased arteries and Gensini score.Results The value of C-F PWV in the group with 3-vessel disease was significantly higher than that in the group without CAD(P=0.001).Univariate linear regression analysis showed that C-F PWV was related to Gensini score,with correlation coefficient R=0.701.Logistic regression analysis showed that gender and C-F PWV are the independent predictor of 3-vessel coronary artery disease.Conclusion C-F PWV was significantly correlated with the extent of coronary artery stenosis,and high C-F PWV can be regarded as an independent predictor of 3-vessel coronary artery disease.So high C-F PWV may be regarded as a marker of CAD,which is helpful to evaluate the severity of coronary atherosclerotic heart disease.

Key words: pulse wave velocity, coronary atherosclerosis, Gensini score