Biomarkers in predicting renal replacement therapy in acute septic kidney injury

doi:10.3969/j.issn.1006-7795.2013.02.005

Abstract

Abstract:

Objective To evaluate whether the serum neutrophil gelatinase associated lipocalin(sNGAL), urinary neutrophil gelatinase lipocalin(uNGAL), urinary interleukin-18(uIL-18) or urinary kidney injury molecule-1(uKIM-1) can predict the need for renal replacement therapy(RRT)in patients with septic acute kidney injury(AKI). Methods A prospective observational study was conducted in patients with septic AKI whose expected ICU stay ≥24 h. AKI was defined by American Kidney Injury(AKIN) criteria during the 48 h after admission, while sNGAL, uNGAL, uIL-18 and uKIM-1 were determined at the enrollment. Test characteristics were calculated to assess the diagnostic performance of these biomarkers. Results Forty-five patients were studied, RRT was initiated in 12 patients with septic AKI in the first 7 days. Two groups were defined according to the need of RRT: RRT group(n=12) and non-RRT group(n=33). RRT group had higher median uNGAL level compared to non-RRT group(912.0 vs 218.0 ng/mL, P<0.001). The predicting performance for uNGAL was good(AUC 0.88), and that of sNGAL, uIL-18 and uKIM-1 was poor(AUC 0.68,0.69,0.67, respectively). Conclusion uNGAL might be a good biomarker for predicting the need of RRT in patients with septic AKI.

Key words: sepsis, acute kidney injury, renal replacement therapy, neutrophil gelatinase associated lipocalin, kidney injury molecule-1, interleukin-18

CLC Number:

JIANG Bo, JIANG Li, XI Xiuming. Biomarkers in predicting renal replacement therapy in acute septic kidney injury[J]. Journal of Capital Medical University, 2013, 34(2): 187-190.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.02.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I2/187

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