Association between single nucleotide polymorphisms in NOS2 gene and house dust mite-sensitive allergic rhinitis

doi:10.3969/j.issn.1006-7795.2018.01.010

Journal of Capital Medical University ›› 2018, Vol. 39 ›› Issue (1): 51-56.doi: 10.3969/j.issn.1006-7795.2018.01.010

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Association between single nucleotide polymorphisms in NOS2 gene and house dust mite-sensitive allergic rhinitis

Li Jingyun¹, Zhang Yuan¹, Zhang Luo^1,2

1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing 100730, China;
2. Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2017-12-11 Online:2018-01-21 Published:2018-01-27
Supported by:
This study was supported by National Natural Science Foundation of China (81420108009,81630023, 81400447, 81570895), Changjiang Scholars and Innovative Research Team (IRT13082), Beijing Talent Project (2016), Beijing Health Bureau Program for High Level Talents (2009-2-007, 2011-3-043, and 2014-3-018), Beijing Municipal Administration of Hospitals' Mission Plan (SML20150203), Beijing Scientific and Technological Overall Plan (Z171100000117002).

Abstract

Abstract: Objective To investigate the association between single nucleotide polymorphisms(SNP) in NOS2 gene and house dust mite-sensitive allergic rhinitis(HDM-sensitive AR).Methods A total of 385 HDM-sensitive AR patients and 424 control subjects were enrolled and genomic DNA was extracted from peripheral blood leucocytes of each participant. A total of 6 reprehensive marker SNPs in NOS2 were genotyped using Sequenom iPLEX MassARRAY platform.Results The allele frequency analysis did not show any significant associations between 6 SNPs in NOS2 and HDM-sensitive AR. The genotype analysis showed the significant difference in distribution of rs3794764_(AA+AG) between HDM-sensitive AR patients and controls(P=0.047). The rs3794764_(AA+AG vs GG) presented a risk among HDM-sensitive AR patients(OR=1.413,95% CI:1.005-1.987). Multiple linear regression analysis indicated that only rs3794766 in NOS2 gene was significantly associated with total serum IgE levels in control group (P=0.019, β=-0.131,95% CI:-0.229- -0.021.Conclusion NOS2 genes variabilities might be associated with HDM-sensitive AR susceptibility in Han Chinese.

Key words: house dust mite-sensitive allergic rhinitis, nitric oxide synthase 2, single nucleotide polymorphism, association study

CLC Number:

R765.21

Li Jingyun, Zhang Yuan, Zhang Luo. Association between single nucleotide polymorphisms in NOS2 gene and house dust mite-sensitive allergic rhinitis[J]. Journal of Capital Medical University, 2018, 39(1): 51-56.

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Association between single nucleotide polymorphisms in NOS2 gene and house dust mite-sensitive allergic rhinitis

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