Identification of protein-coding genes regulated by aberrant methylation in glioblastoma

doi:10.3969/j.issn.1006-7795.2021.01.012

Abstract

Abstract: Objective By integrating multi-omics data, we identified protein-coding genes (PCGs) regulated by DNA methylation in glioblastoma (GBM), evaluated the biological functions of PCGs under different methylation patterns, and explored the risk markers associated with GBM prognosis. Methods Based on multi-omics data, we constructed the DNA methylation profiles of PCGs in GBM, screened PCGs whose expression was regulated by aberrant methylation and functional enrichment analysis. Meanwhile, we performed survival analysis of the selected PCGs by combining with GBM clinical data. Results 630 PCGs whose expression was regulated by aberrant methylation were identified, and 51 PCGs associated with GBM prognosis were excavated. Conclusions The potential PCGs whose expression were regulated by aberrant methylation were identified systematically, and we provide a novel insight for identifying GBM risk markers and potential therapeutic targets.

Key words: glioblastoma, protein-coding genes, DNA methylation, regulation, biomarkers

CLC Number:

R318

Ji Jianghuai, Zhao Xiaoxiao, Li Qianpeng, An Yi, Zhao Lei, Li Dongguo. Identification of protein-coding genes regulated by aberrant methylation in glioblastoma[J]. Journal of Capital Medical University, 2021, 42(1): 71-76.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.01.012

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I1/71

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