Correlation of interleukin-6 and hypersensitive C-reactive protein with cerebral venous and sinus thrombosis in perinatal stage

doi:10.3969/j.issn.1006-7795.2021.02.008

Abstract

Abstract: Objective To investigate the correlation between inflammatory cytokines including interleukin-6 (IL-6), hypersensitive C-reactive protein (Hs-CRP) and cerebral venous sinus thrombosis (CVST) during perinatal period.Methods A total of 39 cases of pregnant and puerperal women diagnosed with CVST who were hospitalized in Xuanwu Hospital, Capital Medical University from January 2010 to January 2020 were retrospectively analyzed, and 80 cases were randomly selected as the control group. The values of IL-6 and Hs-CRP in the acute and convalescence stages of CVST group were detected, and the relationship between IL-6, Hs-CRP in the perinatal period and the formation of CVST was analyzed. Results IL-6 and hs-CRP were higher in CVST group, than those in control group and there was statistical difference between the two groups (P<0.05). The level of IL-6 and hs-CRP in the acute stage were significantly higher than that in the recovery stage, and the difference was statistically significant (P<0.05). The results of the multivariate Logistic regression analysis indicated that the high level of IL-6 was positively correlated with CVST. (OR=4.280,95%CI 1.790-10.232). However,there was no significant correlation with Hs-CRP(OR=0.930,95%CI=0.830-1.042).Conclusion When the level of IL-6 and hs-CRP, especially IL-6, increased in the pregnant women with risk factors, the occurrence of CVST should be vigilant.IL-6 and hs-CRP were significantly increased in the acute stage of CVST. After treatment, the expression of inflammatory factors gradually decreased and tended to be normal in the convalescence stage, which could be used to evaluate the short-term prognosis of the disease.

Key words: inflammatory cytokines, interleukin-6, hypersensitive C-reactive protein, cerebral venous sinus thrombosis, perinatal period

CLC Number:

Zhang Xinhong, Yang Chuqi, Wang Xuan, Shen Xiaguang, Fang Chun, Wang Fengying. Correlation of interleukin-6 and hypersensitive C-reactive protein with cerebral venous and sinus thrombosis in perinatal stage[J]. Journal of Capital Medical University, 2021, 42(2): 210-213.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.02.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I2/210

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