Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (2): 273-279.doi: 10.3969/j.issn.1006-7795.2021.02.019

• Clinical Research • Previous Articles     Next Articles

Screening analysis of tuberculosis patients and their close contacts in some schools in Beijing

Duan Huijuan1, Dai Guangming1, Chu Hongqian1, Yang Zhen2, Bao Cheng2, He Yanping2, Sun Zhaogang1, *   

  1. 1. Translational Medicine Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;
    2. Prevention Control Department, Beijing Changping Institute for Tuberculosis Prevention and Treatment, Beijing 102200,China
  • Received:2020-07-21 Published:2021-04-26
  • Contact: *E-mail:sunzg75@163.com
  • Supported by:
    This study was supported by National Science and Technology Major Project of China(2018ZX10103001).

PDF

42

Abstract: Objective To understand the prevalence of tuberculosis among students by screening and analyzing tuberculosis patients and their close contacts in some schools in Beijing for the provide theoretical guidance for the prevention and control of tuberculosis in schools at different stages.Methods The tuberculosis patients and their close contacts found in the schools at different stages from 2015 to 2018 were collected as the research object. A total of 6 215 cases of data were included in this study, including 114 index cases and 6 101 close contacts. The close contacts were determined by tuberculin skin test with purified protein derivative(PPD) and X-ray chest radiography to identify potential tuberculosis patients, and to analyze the related risk factors of close contacts. Results Among close contacts,a total of 29 cases of tuberculosis were screened out, including 22 male (75.86%) and 7 female (24.14%); vocational schools and universities had higher rates of tuberculosis, 41.38%(12/29) and 48.28%(14/29), respectively, which mainly were students. Among close contacts, 2206 cases (36.16%) were positive for PPD (induration diameter≥5 mm) and 676 cases (11.08%) were strong positive (induration diameter≥15 mm); The positive rate of PPD from kindergarten to university showed an upward trend, with statistically difference (χ2=59.879,P<0.05), and the detection rate of tuberculosis gradually increased, with statistical difference(χ2=8.403,P=0.015). With the increase of PPD induration, the detection rates of tuberculosis also increased and the Chi-square test was statistically different(χ2=168.509,P<0.05). Conclusion Screening of close contacts of tuberculosis in schools of different ages should focus on the students at the vocational and university. At the same time, new methods should be adopted to improve the sensitivity of tuberculosis tests, to detect infected people early, and to avoid tuberculosis outbreaks in schools.

Key words: close contact, purified protein derivative, students, tuberculosis screening

CLC Number: