Meta-analysis of risk factors for bloodstream infections in intensive care unit

doi:10.3969/j.issn.1006-7795.2021.06.004

Abstract

Abstract: Objective To investigate the risk factors of bloodstream infections (BSI) in intensive care unit (ICU). Methods We screened the studies in English databases (Cochrane Library, PubMed, Embase, Web of Science) and Chinese databases (CBM, CNKI, Wanfang, Weipu) from each starting year to April 2021.Two investigators independently reviewed the articles and extracted the information according to the established inclusion and exclusion criteria, and cross-checked. Data analysis was performed by the software RevMan5, and the heterogeneity among the study and risk of bias were also evaluated. Results Among the initial identified 13 691 articles, 11 studies were brought into study. Our results showed that risk factors of BSI are parenteral nutrition (OR=5.07,95%CI:2.89-9.10), respiratory failure(OR=3.03,95%CI:1.90-4.83), sepsis(OR=2.13,95%CI:1.50-3.01), central venous catheterization(OR=3.57,95%CI:2.16-5.90), immunosuppression(OR=3.52,95%CI:1.72-7.20),mechanical ventilation(OR=5.28,95%CI:2.05-13.62), cardiovascular events(OR=3.07,95%CI:1.68-5.62), and previous antibiotic exposure(OR=2.46,95%CI:1.14-5.33). Conclusion The risk factors of BSI in the ICU included parenteral nutrition, respiratory failure, sepsis, central venous catheterization, immunosuppression, mechanical ventilation, cardiovascular events, and previous antibiotic exposure.

Key words: bloodstream infections, risk factors, intensive care unit

CLC Number:

R195.4

Qi Zhili, Lin Jin, Dong Lei, Liu Jingfeng, Duan Meili. Meta-analysis of risk factors for bloodstream infections in intensive care unit[J]. Journal of Capital Medical University, 2021, 42(6): 923-930.

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