The progress in the role and application of neutrophils in glioma

doi:10.3969/j.issn.1006-7795.2025.03.008

Abstract

Abstract: Neutrophils are the most abundant white blood cells in the human body and play different roles in various diseases. The studies have shown that inflammation is closely related to the occurrence and development of tumors. As an important component of the tumor microenvironment (TME), neutrophils play a crucial role in tumors and have a dual effect of promoting and inhibiting tumor growth. This article deeply discusses the recruitment and subtypes of neutrophils, as well their dual effects on tumors. Meanwhile, it illustrates the role and clinical significance of neutrophils in gliomas. The therapeutic approach of targeting neutrophils in tumors provides a new direction for subsequent tumor treatment. Especially for central nervous system tumors, neutrophils as carriers can transport chemotherapeutic drugs across the blood-brain barrier to reach the tumor tissue, offering new hope for the subsequent treatment of brain tumors.

Key words: inflammation, neutrophils, neutrophil extracellular traps, , tumors, gliomas

CLC Number:

R739.4

Jiang Haiping, Yin Shuo, Li Shenglan, Li Wenbin. The progress in the role and application of neutrophils in glioma[J]. Journal of Capital Medical University, 2025, 46(3): 448-454.

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