Abstract:

Nonalcoholic fatty liver(NAFL) was the manifestation of the metabolic syndrome. More and more importance has been attached to the high incidence of NAFL. Although the mechanism of nonalcoholic fatty liver is remains undetermined most investigators accept to the second-hit theory.This article has focused on the research advances of insulin resistance in itochondrial dysfunction, cytochromes P450-2E1, and we understand the interaction of multiple factors which induce nonalcoholic fatty liver. It means that teamtherapy will improve the efficacy of clinic treatment.In addition, maybe Traditional Chinese Medicine will be suitable for the therapy because of its advantage of multi-factor integrated treatment. It will have much benefit that using classical Traditional Chinese Medicine to treat nonalcoholic fatty liver on the basis of studying mitochondria, CYP2E1 and insulin.

Key words: nonalcoholic fatty liver, mechanism, insulin, mitochondria, CYP2E1