Abstract: To determine the role of verapamile in induction of acute heart failure, Inj. Verapamile and ten dogs were used in the experiment. The experimental procedure is as follows: ① general anesthesia and insertion of the monitoring lines, ② induction of acute heart failure with Verapamile, ③ the collection of data, ④ statisticse. The result shows that: after a satisfied induction of heart failure, there is a significant decrease in aortic systolic pressure (-29%), aortic diastolic pressure (-18.5%), +d p /d t (-47.5%), -d p /d t (57.5%), HR (-30.6%), Cardiac output (-34.2%), endocardial viability ratios (-13.8%), and coronary flow (-40.3%). However there is a significant increase in pulmonary capillary wedge pressure (70.5%). In conclusion, in the acute experiment, the administration of Verapamile is an effective mothed in animal model of heart failure.

Key words: verapamile, heart failure, animal model