Journal of Capital Medical University ›› 2002, Vol. 23 ›› Issue (2): 107-109.

• 基础研究 • Previous Articles     Next Articles

Synthesis and Structure-relationship of a New Kind of Inhibitor of Mercapto-proteinases

Chen Gaiqing1, He Jie1, Zhang Feng1, Li Yuying2, Li Yulan2   

  1. 1. Department of Chemistry, Capital University of Medical Sciences;2. Department of Microbiology, Capital University of Medical Sciences
  • Received:2001-02-23 Revised:1900-01-01 Online:2002-04-15 Published:2002-04-15

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Abstract: A new kind of antibiotics containing Tetrahydro-2H-1,3,5-thiadiazine-2-thione(THTT)was studied. According to the basic structure-relationship of THTT, the antimicrobial activity is mainly depended on the C3-substituents. The structure of these compounds were confirmed by UV, IR, H-NMR and elemental analysis. The in vitro activity of the compounds against 6 kinds of bacteria was tested. The antimicrobial activities of all compounds were more potent than sulfadiazine sodium, especially the benzal-substituent THTT, which suggest that it may be worth studying further.

Key words: antimicrobial activities|thiadiazine-2-thione|structure-activity relation

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