Role of JNK Signaling Pathway Involved in the Cochlea of Aged Rats

doi:10.3969/j.issn.1006-7795.2009.06.004

Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (6): 741-745.doi: 10.3969/j.issn.1006-7795.2009.06.004

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Role of JNK Signaling Pathway Involved in the Cochlea of Aged Rats

XIE Jing¹, LUO Ling-hui², XUE Qiu-hong³, GONG Shu-sheng¹

1. Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University;2. Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology;3. Department of Otorhinolaryngology, Medical College of Wuhan Science and Technology University

Received:2009-09-22 Revised:1900-01-01 Online:2009-12-21 Published:2009-12-21

Abstract

Abstract: Objective To explore the involvement of c-Jun amino-terminal kinase pathway(JNK, also known as stress-activated protein kinase/SAPK) in the cochlear of aged rats. Methods Hearing threshold was detected with auditory brainstem response(ABR). Transmission electron microscopy(TEM) was used to observe the ultrastructure of cochlear. In addition, expression of p-JNK and p-c-Jun were detected by immunohistochemistry and Western blotting. Results Auditory threshold in the aged group〔(72.083±13.345)dBSPL〕 was elevated compared to the control group〔(32.083±3.878)dBSPL〕, P<0.01). Accordingly, apoptosis was confirmed in the cochlea from aged group by TEM. The expression of p-JNK and p-c-Jun were significantly increased in the aged groups(P<0.05). Conclusion The activation of JNK singling pathway maybe contributed to the apoptosis of aged cochlear, which probably provided more possibility in prevention and treatment of the presbycusis.

Key words: inner ear, presbycusis, c-Jun amino-terminal kinase, apoptosis

CLC Number:

R 764.43⁺6

XIE Jing;LUO Ling-hui;XUE Qiu-hong;GONG Shu-sheng. Role of JNK Signaling Pathway Involved in the Cochlea of Aged Rats[J]. Journal of Capital Medical University, 2009, 30(6): 741-745.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2009.06.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2009/V30/I6/741

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Role of JNK Signaling Pathway Involved in the Cochlea of Aged Rats

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