Journal of Capital Medical University ›› 2013, Vol. 34 ›› Issue (3): 450-453.doi: 10.3969/j.issn.1006-7795.2013.03.025

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Relationship between serum level of fibroblast growth factor 23 and phosphorus and parathyroid hormone in dialysis patients

XU Fengbo, LIU Huilan, SUN Yi   

  1. Department of Nephrology, Fuxing Hospital, Capital Medical University, Beijing 100038, China
  • Received:2012-04-10 Online:2013-06-21 Published:2013-06-17
  • Supported by:

    This study was supported by Youth Foundation of Fuxing Hospital(YQN201213).

Abstract:

Objective To determine the serum level of fibroblast growth factor 23 (FGF23) in maintenance hemodialysis (MHD) patients and explore the relationship between FGF23 and phosphorus and serum parathyroid hormone (PTH). Methods Fifty MHD patients and thirty healthy persons (control group) whose renal functions were normal were enrolled in this study. According to the PTH level, MHD patients were divided into three groups: group A1(PTH<300 pg/mL), group A2(PTH 300-500 pg/mL), group A3(PTH>500 pg/mL). Phosphate, calcium, alkaline phosphatase in their serum were determined too. The level of FGF23 and 1,25-(OH)2D3 in serum were detected by the method of ELISA. Results ①The Log FGF23 in MHD group was much higher than that of control, Log1,25-(OH)2D3 in MHD group was lower than that of control. ②The Log FGF23 in group A3 was much higher than group A1.③Log FGF23 was positively correlated with serum phosphorus, Log PTH and Log ALP,negatively correlated with Log 1,25-(OH)2D3. ④Multiple linear regression analysis revealed that the level of serum level of FGF23 in MHD patients was extremely high. Conclusion The serum level of FGF23 in MHD patients was extremely high.

Key words: fibroblast growth factor 23, 1,25-dihydroxy-cholecalciferol, parathyroid hormone, maintenance hemodialysis

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