Abstract:

Objective To investigate the causes and possible mechanism and pathogenesis of endometrial polyps(EP) by evaluating the expression of estrogen receptor(ER),progesterone receptor(PR) so as to try to find the theoretical basis for the treatment and prevention of EP.Methods Prospective study was performed 56 patients,who had transcervical resection of polyps(TCRP) were enrolled.EP and pieces of endometrium had been removed in all operations.Routine pathological diagnosis to all specimens and immunohistochemical staining studies for ER,PR expression in EP and endometrium were made.Serum sex hormones were measured for all patients.Serum sex hormone in 56 patients were all in normal level.Results Expression of ER in gland and stroma of the two groups showed no significant difference(P>0.05).Expression of PR in gland and stroma were significantly decreased in EP group(P<0.05).Conclusion The main mechanisms of EP may be local endometrium wasn't sensitive to the periodic changes of steroid.Abnormal expressions of PR in EP were probably associated with EP formation.

Key words: endometrium polyps, estrogen receptor, progesterone receptor