The Biologic Significance of Wnt Signaling Pathway in Lung Disease

Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (2): 182-184.

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The Biologic Significance of Wnt Signaling Pathway in Lung Disease

YU Xiao-min^1,2,3, WANG Chen^1,3, WANG Jun^2,3

1. Department of Respiratory Disease, Beijing Chaoyang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine;2. Department of Physiology, School of Basic Medical Sciences, Capital Medical University;3. Department of Respiratory, Capital Medical University

Received:2008-12-18 Revised:1900-01-01 Online:2009-04-21 Published:2009-04-21

Abstract

Abstract:

The Wnt signaling pathway is a highly conserved signaling pathway. It mainly consists of the canonical Wnt/β-catenin pathway and the non-canonical pathway〔the Wnt/planar cell polarity(PCP) pathway and the Wnt/Ca²⁺ pathway〕. Wnt pathway is involved in a wide range of biological functions, such as cell adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence have suggested that the activation of Wnt signaling pathway is substantially involved in the pathogenesis of several pulmonary diseases, such as idiopathic pulmonary arterial hypertension, asthma, idiopathic pulmonary fibrosis and lung cancer. This review focuses on the biological significance of Wnt signaling pathway in lung diseases.

Key words: Wnt signaling, pulmonary arterial hypertension, asthma, idiopathic pulmonary fibrosis, lung cancer

CLC Number:

R 563
R 332

YU Xiao-min;;WANG Chen;WANG Jun. The Biologic Significance of Wnt Signaling Pathway in Lung Disease[J]. Journal of Capital Medical University, 2009, 30(2): 182-184.

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The Biologic Significance of Wnt Signaling Pathway in Lung Disease

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