The change of prefrontal Oxy-Hb peak concentration and the time to peak in patients with different degree depression after stroke

doi:10.3969/j.issn.1006-7795.2017.01.020

Abstract

Abstract: Objective To investigate the change of oxygenate hemoglobin(Oxy-Hb)peak concentration and the time to peak in prefrontal brain lobe in post stroke depression patients with different degrees and to move forward a single step for discussing whether can use functional near-infrared spectroscopy to assist in early diagnosis of depression after stroke.Methods Via functional near-infrared spectroscopy to test 93 patients with PSD (mild depression group 27 cases, moderate depression group 19 cases,major depression group 18 cases)and 29 controls. All subjects completed verbal fluency test in which they were asked to make words as many as possible according to one of three words. The peak level of Oxy-Hb and the time to peak was analyzed in patients with PSD and the control when they completed baseline and verbal fluency test. Results The peak level of Oxy-Hb was (0.29±0.17)mmol·L^-1·mm and the time to peak was (74.27±24.12) s in mild depression group patients with PSD. In moderate depression group,the peak level of Oxy-Hb was (0.17±0.11)mmol·L^-1·mm and the time to peak was (95.14±70.35)s. And in major depression group,the peak level of Oxy-Hb was (0.16±0.30)mmol·L^-1·mm and the time to peak was (125.95±25.68)s. The controls were (0.32±0.10)mmol·L^-1·mm and (69.23±41.78)s. The peak level and the time to peak in mild depression group had no statistically significant difference compared with the control group. Patients with moderate depression group and the control group were different significantly only in Oxy-Hb peak concentration. Only patients with major depression group and control group patients were statistically significant both in the peak level and the time to peak. Conclusion Oxy-Hb peak concentration is one of the more sensitive biological indexes which can be used for the observation of moderate and major patients with PSD. The time to peak applied only to patients with major depression. For patients with mild depression these two indexes were not applicable.

Key words: stroke, depression, Oxy-Hb peak concentration, time to peak

CLC Number:

R743.3

Yang Zhiquan, Liu Aixian, Nie Yiqiu. The change of prefrontal Oxy-Hb peak concentration and the time to peak in patients with different degree depression after stroke[J]. Journal of Capital Medical University, 2017, 38(1): 97-102.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.01.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I1/97

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