Cognitive function of schizophrenia patients after modified electroconvulsive therapy based on neuropsychological and physiological assessment

doi:10.3969/j.issn.1006-7795.2018.05.006

Abstract

Abstract: Schizophrenia is a common chronic mental illness in psychiatry. The disease has a poor prognosis and is prone to recurrence, which places a heavy burden on families and society. There are various treatments for schizophrenia. In addition to medical treatment, modified electroconvulsive therapy (MECT) is the main treatment in physical therapy. Although MECT has many advantages in treatment, the cognitive side effects caused by MECT have been a difficult problem in the clinic. Most previous studies have suggested that MECT has a detrimental effect on cognitive function in patients with schizophrenia. But this traditional view has been challenged in recent years, and more and more studies have shown that MECT may improve its cognitive function on the basis of symptom relief. Based on this, we summarize the research on the impact of MECT on cognitive function in recent years, and then analyze its impact on cognition and possible mechanisms.

Key words: modified electroconvulsive therapy, schizophrenia, cognitive function

CLC Number:

R749

Liu Yi, Ren Yanping, Jiang Wei, Ma Xin. Cognitive function of schizophrenia patients after modified electroconvulsive therapy based on neuropsychological and physiological assessment[J]. Journal of Capital Medical University, 2018, 39(5): 651-656.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.05.006

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I5/651

References

[1] Phillips M R, Zhang J, Shi Q, et al. Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001-05:an epidemiological survey[J]. Lancet,2009,373(9680):2041-2053.
[2] No author listed. Adjunctive electroconvulsive therapy for schizophrenia:a meta-analysis of randomized rater-masked controlled trials[J]. J ECT,2016,32(4):276.
[3] Zheng W, Tong G, Ungvari G S, et al. Memory impairment following electroconvulsive therapy in Chinese patients with schizophrenia:meta-analysis of randomized controlled trials[J]. Perspect Psychiatr Care,2018,54(2):107-114.
[4] 魏丽秀,胡洪进,童爱群. 药物合并无抽搐电痉挛治疗对精神分裂症患者记忆和认知功能的影响[C]. 2011年浙江省医学会精神病学分会学术年会暨浙江省医师协会精神科医师分会第四届年会,浙江慈溪,2011.
[5] 闾金杰,杨永杰,李海玲,等. 无抽搐电休克治疗对精神分裂症患者执行功能的影响[J]. 中国健康心理学杂志,2013,21(10):1443-1445.
[6] de la Serna E, Flamarique I, Castro-Fornieles J, et al. Two-year follow-up of cognitive functions in schizophrenia spectrum disorders of adolescent patients treated with electroconvulsive therapy[J]. J Child Adolesc Psychopharmacol,2011,21(6):611-619.
[7] 李桦,吴荣琴,孙复林. 无抽搐电休克治疗对精神分裂症的效果及患者认知功能的影响[J]. 四川精神卫生,2014(5):418-421.
[8] 龚世灵,黄金伟,陈汉明. 无抽搐电休克治疗精神分裂症前后认知功能的变化[J]. 泰山医学院学报,2016,37(7):765-766.
[9] Semkovska M, Mcloughlin D M. Objective cognitive performance associated with electroconvulsive therapy for depression:a systematic review and meta-analysis[J]. Biol Psychiatry,2010,68(6):568-577.
[10] 吴大兴,谭长连,颜莉蓉,等. 伴有执行功能障碍的精神分裂症患者汉字工作记忆前额叶激活模式[J]. 中国行为医学科学,2008,17(2):134-137.
[11] 杨桂芬,张云亭,张权,等. 前额叶皮层在数字工作记忆维持中的作用:事件相关fMRI研究[J]. 实用放射学杂志,2007,23(12):1588-1591.
[12] Sackeim H A, Prudic J, Fuller R, et al. The cognitive effects of electroconvulsive therapy in community settings[J]. Neuropsychopharmacology,1992,32(1):244-254.
[13] Lui S S, Wang Y, Liu A C, et al. Prospective memory in patients with first-onset schizophrenia and their non-psychotic siblings[J]. Neuropsychologia,2011,49(8):2217-2224.
[14] Wang Y, Chan R C, Yu X, et al. Prospective memory deficits in subjects with schizophrenia spectrum disorders:a comparison study with schizophrenic subjects, psychometrically defined schizotypal subjects, and healthy controls[J]. Schizophr Res,2008,106(1):70-80.
[15] Ingram A, Saling M M, Schweitzer I. Cognitive side effects of brief pulse electroconvulsive therapy:a review[J]. J ECT,2008,24(1):3-9.
[16] Andrade C, Arumugham S S, Thirthalli J. Adverse effects of electroconvulsive therapy[J]. Psychiatr Clin North Am,2016,39(3):513-530.
[17] Kho K H, Vanvreeswijk M F, Murre J M. A retrospective controlled study into memory complaints reported by depressed patients after treatment with electroconvulsive therapy and pharmacotherapy or pharmacotherapy only[J]. J ECT,2006,22(3):199-205.
[18] Twamley E W, Woods S P, Zurhellen C H, et al. Neuropsychological substrates and everyday functioning implications of prospective memory impairment in schizophrenia[J]. Schizophr Res,2008,106(1):42-49.
[19] 阚博. 无抽搐电休克治疗对精神分裂症患者前瞻性记忆功能影响的研究[D]. 合肥:安徽医科大学,2014.
[20] Fernie G, Bennett D M, Currie J, et al. Detecting objective and subjective cognitive effects of electroconvulsive therapy:intensity, duration and test utility in a large clinical sample[J]. Psychol Med,2014,44(14):2985-2994.
[21] Mohn C, Rund B R. Significantly improved neurocognitive function in major depressive disorders 6 weeks after ECT[J]. J Affect Disord,2016,202:10-15.
[22] Kumar D R, Han H K, Tiller J, et al. A brief measure for assessing patient perceptions of cognitive side effects after electroconvulsive therapy:the subjective assessment of memory impairment[J]. J Ect,2016,32(4):256-261.
[23] Royle J, Lincoln N B. The everyday memory questionnaire-revised:development of a 13-item scale[J]. Disabil Rehabil,2008,30(2):114-121.
[24] Keefe R S, Goldberg T E, Harvey P D, et al. The brief assessment of cognition in schizophrenia:reliability, sensitivity, and comparison with a standard neurocognitive battery[J]. Schizophr Res,2004,68(2-3):283-297.
[25] Brus O, Nordanskog P, Båve U, et al. Subjective memory immediately following electroconvulsive therapy[J]. J ECT,2016,33(2):96-103.
[26] 张红霞,季建林,王慧芳,等. 药物治疗基础上合并电抽搐治疗对精神分裂症患者的记忆和执行功能的影响[J]. 中国神经精神疾病杂志,2011,37(2):68-71.
[27] 李桦,吴荣琴,孙复林. 无抽搐电休克治疗对精神分裂症的效果及患者认知功能的影响[J]. 四川精神卫生,2014,27(5):418-421.
[28] 杨楹. 无抽搐电休克治疗对精神分裂症患者记忆的远期影响[J]. 精神医学杂志,2015,28(4):278-280.
[29] 张菁,周德祥,徐清,等. MECT对青少年精神分裂症患者执行功能的影响[J]. 精神医学杂志,2014,27(1):30-32.
[30] Sevda B, Ozge C, Murat A I, et al. Early effects of modern electroconvulsive therapy on subjective memory in patients with mania or depression:[J]. Indian Journal of Psychiatry,2016,58(2):198-203.
[31] Luoni A, Berry A, Calabrese F, et al. Delayed BDNF alterations in the prefrontal cortex of rats exposed to prenatal stress:preventive effect of lurasidone treatment during adolescence[J]. Eur Neuropsychopharmacol,2014,24(6):986-995.
[32] Gururajan A, Hill R A, van den Buuse M. Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment[J]. Neuroscience,2015,284:297-310.
[33] Castello N A, Nguyen M H, Tran J D, et al. 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of alzheimer disease-like neuronal loss[J]. PLoS One, 2014,9(3):e91453.
[34] Rizos E, Papathanasiou M A, Michalopoulou P G, et al. A longitudinal study of alterations of hippocampal volumes and serum BDNF levels in association to atypical antipsychotics in a sample of first-episode patients with schizophrenia[J]. PLoS One,2014,9(2):e87997.
[35] Carlino D, De Vanna M, Tongiorgi E. Is altered BDNF biosynthesis a general feature in patients with cognitive dysfunctions?[J]. Neuroscientist,2013,19(4):345-353.
[36] Zhang X Y, Liang J, Chen D C, et al. Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia[J]. Psychopharmacology,2012,222(2):277-284.
[37] 许烨勍,叶尘宇,沈瑜君,等. 血清脑源性神经营养因子与精神分裂症症状及认知功能的关系[J]. 中国神经精神疾病杂志,2011,37(7):425-427.
[38] 袁杰,瞿正万,蔡正宜,等. Ⅰ型、Ⅱ型精神分裂症患者脑源性神经营养因子水平临床分析[J]. 检验医学与临床,2015,12(2):174-176.
[39] 肖文焕. 抗精神病药物和改良电休克治疗对精神分裂症患者血清BDNF、GDNF水平及认知功能的影响[D]. 扬州:扬州大学,2015.
[40] 王军. 改良性电抽搐治疗对精神分裂症患者认知功能影响的视觉P300研究[D]. 南京:南京医科大学,2012.
[41] Royse C F, Andrews D T, Newman S N, et al. The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery[J]. Anaesthesia,2011,66(6):455-464.
[42] Goswami U, Babbar S, Tiwari S. Comparative evaluation of the effects of propofol and sevoflurane on cognitive function and memory in patients undergoing laparoscopic cholecystectomy:a randomised prospective study[J]. Indian J Anaesth,2015,59(3):150-155.
[43] Li X, Lu F, Li W, et al. Underlying mechanisms of memory deficits induced by etomidate anesthesia in aged rat model:critical role of immediate early genes[J].China Med J (Engl),2016,129(1):48-53.
[44] Willis J, Zhu W, Perez-Downes J, et al. Propofol-induced electroencephalographic seizures in neonatal rats:the role of corticosteroids and gamma-aminobutyric acid type a receptor-mediated excitation[J]. Anesth Analg,2015,120(2):433-439.
[45] Xu C, Tan S, Zhang J, et al. Anesthesia with sevoflurane in neonatal rats:developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl^- importer antagonists[J]. Psychoneuroendocrinology,2015,60:173-181.
[46] Tan S, Xu C, Zhu W, et al. Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats[J]. Anesthesiology,2014,121(5):1010-1017.
[47] Xu C, Seubert C N, Gravenstein N, et al. Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats[J]. Neurosci Lett,2016,618:1-5.
[48] Zurek A A, Yu J, Wang D S, et al. Sustained increase inα5GABAA receptor function impairs memory after anesthesia[J]. J Clin Invest,2014,124(12):5437-5441.