Prevalence and prognostic significance of TMPRSS2-ERG fusion gene in prostate cancer with lymph node metastasis

doi:10.3969/j.issn.1006-7795.2019.01.013

Abstract

Abstract: Objective To investigate the distribution and prognostic significance of TMPRSS2-ERG fusion gene in lymph node-positive prostate cancer. Methods Fifty cases of lymph node metastasis after radical prostatectomy from January 2008 to December 2012 were collected. All patients received endocrine therapy after operation. The TMPRRS2-ERG fusion gene was detected with fluorescence in situ hybridization. The data were correlated with various tumor features (Gleason score, stage) and biochemical recurrence-free, disease-specificity, and overall survival. The distribution of clinicopathological data and prognosis of patients were compared with each other for the patients with positive and negative fusion genes. Results The TMPRSS2-ERG fusion gene was detected in 19 cases (38%) of the primary tumors. Fusion genes were present in 16 cases (32%) of the metastatic lymph nodes. The primary tumor and metastatic lesion TMPRSS2-ERG status was in good agreement (Kappa=0.73). The TMPRSS2-ERG fusion gene and Gleason score in primary tumors in COX analysis were predictors of biochemical recurrence. In survival analysis, the prognosis of primary tumors/lymph node fusion gene (+/+) group and primary tumors/lymph node fusion gene (+/-) group was lower than that of primary tumors/lymph node fusion gene (-/-) group, with significant difference in the non-biochemical recurrence rate (P=0.03). Conclusion The positive rate of TMPRSS2-ERG fusion gene in primary prostate cancer with lymph node metastasis was 38%. The fusion gene of TMPRRS2-ERG in primary tumors and lymph node metastases had good consistency (Kappa=0.73). Patients with positive primary tumor TMPRSS2-ERG fusion gene have a poor prognosis.

Key words: TMPRSS2-ERG, prostate cancer, metastases, survival

CLC Number:

R737.25

Xie Yingwei, Jin Shipeng, Yan Wei, Wang Wei, Ping Hao, Liu Yuexin. Prevalence and prognostic significance of TMPRSS2-ERG fusion gene in prostate cancer with lymph node metastasis[J]. Journal of Capital Medical University, 2019, 40(1): 72-77.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.01.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I1/72

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