Associations of plasma trimethylamine N-oxide and its precursors with coronary heart disease

doi:10.3969/j.issn.1006-7795.2020.01.019

Abstract

Abstract: Objective To study the associations of plasma trimethylamine N-oxide (TMAO) and its precursors with coronary heart disease (CHD). Methods Patients with suspected CHD were enrolled in cardiology department of Beijing Tiantan Hospital, and divided into CHD and control groups according to angiography results. Plasma TMAO, choline, carnitine, betaine and butyrobetaine of all patients were measured by high-performance liquid chromatography, and the differences of plasma TMAO and its precursors between CHD and control patients were analyzed by statistical methods. Results The difference of plasma TMAO between CHD and control groups was significance[(6.20±3.57)μmol/L vs (3.90±2.26) μmol/L, P<0.05], but the differences of choline, carnitine, betaine and butyrobetaine between two groups were not significant (P>0.05). And plasma TMAO was still associated with CHD significantly in multivariate Logistic regression analysis (OR=1.35, P<0.05). Conclusion CHD was associated with plasma TMAO level significantly, but not its precursors.

Key words: coronary heart disease, trimethylamine N-oxide, choline

CLC Number:

R541.4

Xiong Xiaowei, Guo Caixia, Xu Xiaowei, Mu Liying, Hu Hongyu, Chen Wei, Chen Buxing. Associations of plasma trimethylamine N-oxide and its precursors with coronary heart disease[J]. Journal of Capital Medical University, 2020, 41(1): 99-102.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.01.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I1/99

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