A preliminary study on efficacy for Shi-zhen-an-shen granules on cognitive impairments in prodromal schizophrenia

doi:10.3969/j.issn.1006-7795.2021.03.010

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (3): 404-407.doi: 10.3969/j.issn.1006-7795.2021.03.010

• Integrative Treatment for Mental Disorder • Previous Articles Next Articles

A preliminary study on efficacy for Shi-zhen-an-shen granules on cognitive impairments in prodromal schizophrenia

Ning Yanzhe, Zhu Hong, Song Nan, Zheng Sisi, Li Ziyan, Li Jiajia, Ma Rui, Jia Hongxiao^*

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University & The Advanced Innovation Center for Human Brain Protection, Beijing 100088,China

Received:2021-03-15 Online:2021-06-21 Published:2021-06-16
Contact: *E-mail:jhxlj@vip.163.com
Supported by:
Natural Science Foundation of Beijing (7212050), Capital’s Funds for Health Improvement and Research (2018-1-2122,2020-4-2126), Dengfeng Talents of Beijing Hospital Management Center(DFL20191901), Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support (ZYLX202129), Chinese Medicine Science and Technology Development Found of Beijing (QN2018-27),Talents Training Fund of Beijing(2018000021469G292).

Abstract

Abstract: Objective To investigate efficacy for Shi-zhen-an-shen (SZAS) granules on cognitive impairments in prodromal schizophrenia. Methods A total of 60 eligible participants were randomly assigned to either the treatment group or the control group in a ratio of 1∶1. The participants in the treatment group received SZAS and the placebo of aripiprazole, the control group received placebo of SZAS and aripiprazole. The treatment course had lasted for 4 weeks. Outcome measurements included Trail Making Test A (TMTA), Hopkins Verbal Learning Test-Revised (HVLT-R), Brief Visuospatial Memory Test Revised (BVMT-R),Continuous Performance Test (CPT), and Stroop Color-Word Test (SCWT). Results There were no significant group effects on all cognitive assessments between the two groups. The time effects on TMTA,HVLT-R,BVMT-R,Stroop-word test,SCWT and CPT showed significant differences between the two groups. The SCWT and CPT showed significant interactive effects. Further analysis indicated significant changes on all cognitive assessments in the treatment group after 4-weeks therapy in comparison with baseline, while only HVLT-R, BVMT-R, SCWT and CPT showed significant changes in the control group after 4-weeks treatment. Conclusion Compared with aripiprazole, the SZAS could improve cognitive impairment more widely. Longer time treatment may support that the SZAS is better than aripiprazole on improving cognitive impairments.

Key words: Shi-zhen-an-shen granules, prodromal schizophrenia, cognitive impairment

CLC Number:

R749.3

Ning Yanzhe, Zhu Hong, Song Nan, Zheng Sisi, Li Ziyan, Li Jiajia, Ma Rui, Jia Hongxiao. A preliminary study on efficacy for Shi-zhen-an-shen granules on cognitive impairments in prodromal schizophrenia[J]. Journal of Capital Medical University, 2021, 42(3): 404-407.

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A preliminary study on efficacy for Shi-zhen-an-shen granules on cognitive impairments in prodromal schizophrenia

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