Effect of body fat percentage on muscle strength and physical performance in the elders with type 2 diabetes mellitus

doi:10.3969/j.issn.1006-7795.2022.04.020

Abstract

Abstract: Objective To explore the association between body fat percentage and muscle strength and physical performance in old people with type 2 diabetes mellitus (T2DM). Methods A total of 127 old people aged more than 60 years who were admitted in the Department of Endocrinology, Xuanwu Hospital, Capital Medical University were included in the study. Levels of glycosylated hemoglobin A1c (HbA1c), 25-hydroxyvitamin D₃, [25(OH)D₃],fasting insulin (FINS), serum C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Body fat percentage and appendicular skeletal muscle mass (ASM) were assessed by dual energy X-ray absorptiometry (DEXA). Muscle strength was assessed using hand-grip strength (HS) and chair stands test. Gait speed (GS) and the Short Physical Performance Battery (SPPB) were used to evaluate physical performance. Multiple linear regression analysis was used to evaluate the association between fat percentage and muscle strength, physical performance. Results Female participants had higher body fat percentage than male subjects (35.18%±6.32% vs 28.75%±4.48%, P＜0.001). Body fat percentage were negatively correlated with ASM, appendicular skeletal muscle mass index (ASMI),hand-grip strength,gait speed,SPPB score, while it was positively correlated with serum levels of CRP, HOMA-IR and chair stands time (P＜0.01). After adjusting age, sex, ASM, HbA1c and high waist circumference, body fat percentage was inversely associated with hand-grip strength and gait speed (β=-33.68,P=0.003; β=-1.316,P=0.002, respectively),while it was positively associated with increased chair stands time (β=31.60,P=0.011). Conclusion Body fat percentage were associated with lower muscle strength and poor physical performance in old people with T2DM.

Key words: type 2 diabetes mellitus, body fat percentage, handgrip strength, physical performance, obesity

CLC Number:

R587.l

Xiu Shuangling, Fu Junling, Mu Zhijing, Sun Lina, Zhao Lei. Effect of body fat percentage on muscle strength and physical performance in the elders with type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2022, 43(4): 641-646.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.04.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I4/641

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