Abstract: Objective To investigate the expression of EDA region of fibronectin(FN) in salivary adenoid cystic carcinoma(SACC) cells and deduce the relationship between EDA and SACC biological characteristic.Methods Immunohistochemistry and reverse transcriptase polymerase chain reaction(RT-PCR) techniques were used to detect EDA region proteins and mRNAs in different metastatic potential SACC cells.Results The expression of EDA region proteins and mRNAs in high metastatic SACC-LM cells were higher than those in low metastatic SACC-83 cells.Conclusion The expression of EDA region of FN may play an important role in the invasion and metastasis of SACC.

Key words: salivary adenoid cystic carcinoma(SACC), fibronectin(FN), EDA region, metastasis