Abstract: Objective To evaluate correlation between hepatic damage or hepatic fibrosis and liver function including total bile acid,alanine aminotransferase or quantity of serum HBV DNA in patients with chronic hepatitis B.Methods eighty-two biopsies in patients with chronic hepatitis B were reviewed pathohistologically.Serum samples for liver function test and quantity of HBVDNA were collected simultaneously half a month before and after the biopsy.The correlations between the results were assessed.Results The inflammatory staging and fibrotic scoring grading were significantly correlated with total bile acid,and inflammatory staging correlated with alanine aminotransferase or quantity of serum HBV DNA.Conclusion Serum total bile acid is considered to be the valuable reference for clinical diagnosis for hepatic inflammatory and fibrosis staging and alanine aminotransferase and the quantity of serum HBVDNA to be valuable for hepatic inflammation.

Key words: hepatitis B, liver function, pathohistology, HBV DNA