Abstract: Objective To investigate the correlation between diabetic peripheral neuropathy(DPN) and hemorrheology and to observe the efficacy effect of pentoxifylline and micobalamin for DPN. Methods 96 patients with DPN were divided into groups of DPN 1, DPN 2 and DPN 3 randomly. Patients of group DPN 1 were treated with micobalamin PO. Patients of group DPN 2 were admistered pentoxifylline PO. Patients of group DPN 3 were treated with both pentoxifylline and micobalamin. Control group are included 36 healthy persons and 40 DM patients without complication. Patients of group DPN 1, DPN 2, DPN 3 were treated for 3 months. Hemorheology and electromyogram were performed prior and post to treatment. Results 1) Whole blood hypsiviscosity, whole blood hypoviscosity, plasma viscosity, fibrinogen, max platelet packing fraction, erythrocyte aggregation of DM patients without complication were higher than healthy persons(P<0.01). Numerical value of prior treatment in group DPN 1, DPN 2 and DPN 3 were higher than DM patients without complication(P<0.01). 2) Nerve conduction velocity(NCV) of post-treatment in group DPN 1, DPN 2 and DPN 3 were improve obviously(P<0.01). In the improve degree of NCV group DPN 2 was better than group DPN 1, DPN 3 was better than group DPN 2(P<0.01). Conclusion Hemorrheology abnormality is an important pathogenic factor in the diabetic peripheral neuropathy. Pentoxifylline and micobalamin can reduce blood viscosity and improve NCV. Among all the therapies alliance is more utility.

Key words: diabetes, peripheral neuropathy, hemorrheology, electromyogram, micobalamin, pentoxifylline