Changes of Neutrophil CD11b in Patients with SARS and Its Clinical Significance

Abstract

Abstract: Objective To investigate the changes of CD11b expression of neutrophil in patients with SARS and its significance.Methods The expressions of CD11b in peripheral blood were quantitatively analyzed by flow cytometry in 86 SARS patients.The patients were divided into 3 groups,including 44 cases of hospital discharge group,33 cases of recovery group(18 cases of common type SARS and 15cases of severe type SARS) and 9 cases of deteriorated group.25 healthy individuals served as the control.CD11b of 13 cases in recovery group and 4 cases in deteriorated group were analyzed again 1 week later.Results The expression of CD11b in the recovery group was significantly higher than that in control group and hospital discharge group(P=0.000,0.003).No significant difference was observed between hospital discharge group and control group(P=0.066).Compared with the expression of CD11b among 9 cases of deteriorated group,15 cases of severe type SARS patients in recovery group and control group,the expression of CD11b in deteriorated group was significantly higher than that in control group(P=0.000).There was no significant difference between deteriorated group and severe type patients in recovery group(P=0.997).The CD11b expression of 13 cases in recovery group was greatly decreased 1 week later(P=0.000).The mean level of CD11b expression of 4 cases in deteriorated group was higher than that 1 week before.Conclusion The adhesive function of PMN is higher in the recovery stage of SARS patients.The dynamic changes of CD11b expression can reflect the prognosis of SARS.

Key words: severe acute respiratory syndrome, neutrophil, adhesive molecule, CD11b

CLC Number:

R563.1

Zhang Lin;Nie Xiuhong;Liu Mingfang. Changes of Neutrophil CD11b in Patients with SARS and Its Clinical Significance[J]. Journal of Capital Medical University, 2006, 27(1): 87-89.

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Changes of Neutrophil CD11b in Patients with SARS and Its Clinical Significance

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