Therapeutic Efficacy of Amlodipine on Blood Pressure Lowering in Patients with Essential Hypertension

Abstract

Abstract: Objective To observe the effects of amlodipine produced in China on clinical blood pressure(CBP) and ambulatory blood pressure monitoring(ABPM) in patients with essential hypertension.Methods Twenty-nine patients with essential hypertension were treated with amlodipine produced in China for 4 weeks.CBPand ABPMwere performed before and after treatment to compare the mean blood pressure of 24 h, daytime and night, pulse pressure, heart rate, load of blood pressure and the circadian rhythm.Results CBP, pulse pressure, load of blood pressure and mean blood pressure of 24 h, daytime and night were significantly reduced.Circadian rhythm was improved markedly.No significant difference was found in heart rate.The effective rate of CBPwas 75.0% and that of ABPMwas 60.4%.The trough to peak ratios for SBPand DBPwere 61% and 64% respectively.Conclusion The blood pressure can be lowered by amlodipine produced in China can significantly and safely.And the circadian rhythm of blood pressure can be improved.

Key words: hypertension, ambulatory blood pressure, amlodipine

CLC Number:

R544.1

Xing Xiurong;Hua Qi;Liu Rongkun;Yang Zheng;Ma Xiangtao;Hou Guishu. Therapeutic Efficacy of Amlodipine on Blood Pressure Lowering in Patients with Essential Hypertension[J]. Journal of Capital Medical University, 2005, 26(6): 722-724.

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Therapeutic Efficacy of Amlodipine on Blood Pressure Lowering in Patients with Essential Hypertension

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