Journal of Capital Medical University ›› 2007, Vol. 28 ›› Issue (1): 10-13.

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The Expression and Significance of CK20mRNA in the Peripheral Blood Samples of Patients with Colorectal Carcinoma before, during and after Radical Operation by Laparoscope or Open Surgery

Wu Jixiang1, Liang Jiexiong1, Wang Yufu1, Li Yajun2, Wen Shaojun3, Li Jinjun1, Shao Tiansong1, Qiu Lixin1, He Ping1   

  1. 1. Department of General Surgery, Beijing Anzhen Hospital, Capital Medical University;2. Department of General Medicine, Beijing Anzhen Hospital, Capital Medical University;3. Beijing Institute of Heart Lung and Blood Vessel Diseases
  • Received:2006-12-16 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24

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Abstract:

Objective To study the alteration of CK20mRNA in the peripheral blood samples by laparoscope and open radical operation of colorectal carcinoma micrometastasis, and investigate the value of laparoscopic surgery in with colorectal cancer. MethodsThe expression of CK20mRNA in the peripheral blood samples of 37 patients with colorectal carcinoma and 8 patients with non-malignant disease by operations on abdomen. Results The expressions of CK20mRNA are negative in the peripheral blood samples of 8 patients with non-malignant disease by operations on abdomen. Meanwhile, the total positive rate of expression with CK20mRNA are 39.6%(44/111)in the patients with colorectal carcinoma. The positive expression rates of CK20mRNA in patients of the two groups pre-, during and post-operation do not have significant difference(P>0.05). Conclusion There are no significant differences in the efficacy of radical operation in patients with colorectal carcinoma by laparoscope and open radical surgery.

Key words: colorectal carcinoma, peripheral blood, micrometastasis, CK20mRNA

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