Abstract: Objective To evaluate effect of plasma volume expansion treatment for preeclampsia by Meta analysis. Methods A comprehensive literature search was performed at PubMed, Medline, Ovid, Embase, CNKI in English language for randomized controlled trials, hand search was also made to retrieve the current reference and research reports. Strict inclusion and exclusion criteria were applied to choose original research, and for quality assessment and data extraction, the software Revman 5.0 was used for the Meta analysis. Results A total of 5 reports met the inclusion criteria of, including a total of 297 patients. Meta analysis results suggest that the volume-expansion group, compared with non-expansion groups: 1 had no statistically significant difference in cesarean section rate, RR = 1.08, 95%CI: 0.96~1.22, P = 0.19, 2the difference in the rate of premature delivery was not statistically significant between two groups, RR = 0.91, 95%CI:0.26~3.22, P = 0.89. 3perinatal mortality rate had no significant difference between the two groups, RR = 1.65, 95%CI:0.77~3.54, P = 0.20.4the proportion of Apgar score <7 had no significant difference between the two groups, RR = 1.11, 95%CI:0.54~2.28, P = 0.77. 5the ratio of an additional drugs had no significant difference, RR = 1.91, 95%CI:0.90~4.05, P = 0.09. Conclusion The volume expansion does not improve the treatment of preeclampsia maternal cesarean section rate, perinatal mortality, Apgar score <7 and the application of an additional drug (magnesium sulfate and antihypertensive drugs) ratio.

Key words: preeclampsia, expand treatment, Meta analysis