Effects of remote ischemic postconditioning on the cerebral ischemia/reperfusion injury and its mechanism

doi:10.3969/j.issn.1006-7795.2013.06.013

Abstract

Abstract:

Objective To study the effects of remote ischemic postconditioning(RIPostC) on cerebral ischemia/reperfusion injury in rats. Methods Three cycles of RIPostC were given immediately after 2 hours of the ischemia in rats.We assessed neurological function before the sacrifice; magnetic resonance imaging(MRI) and hematoxylin-eosin staining were used for determining the infarct volumes at 8 hours, 24 hours, 3 days, 7 days, 14 days, and 30 days after the ischemia. Results Compared with the control groups, the neurological function scores were significantly decreased in R3d and R7d groups(P<0.05). The cerebral infarction volumes were significantly decreased in the R8h, R24h, R3d and R7d groups compared with the control groups(P<0.05). Conclusion RIPostC could reduce the cerebral infarction volumes at 8 h, 24 h, 3 d and 7 d after the cerebral ischemia, and improve the neurological defects in 3 days and 7 days after the cerebral ischemia in the model of middle cerebral artery occlusion(MCAO) in rats.

Key words: stroke, remote ischemic postconditioning, neurological function scores, cerebral infarct volumes

CLC Number:

R743.31

ZHANG Ying, ZHAO Haiping, JI Xunming, GAO Suqin, LUO Yumin. Effects of remote ischemic postconditioning on the cerebral ischemia/reperfusion injury and its mechanism[J]. Journal of Capital Medical University, 2013, 34(6): 844-850.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.06.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I6/844

References

[1] 王伊龙, 王拥军, 吴敌, 等.中国卒中防治现状[J].中国卒中杂志, 2007, 2(1):20-37.
[2] Murry C E, Jennings R B, Reimer K A. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium[J]. Circulation, 1986, 74(5):1124-1136.
[3] Zhao Z Q, Corvera J S, Halkos M E, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning[J]. Am J Physiol Heart Circ Physiol, 2003, 285(1):H579-588.
[4] Kerendi F, Kin H, Halkos M E. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors[J]. Basic Res Cardiol, 2005, 100(5):404-412.
[5] Longa E Z, Weinstein P R, Carlson S, et al. Reversible middle cerebral artery occlusion without craniotomy in rats[J]. Stroke, 1989, 20(1):84-91.
[6] Kim S J, Kim B K, Ko Y J, et al. Functional and histologic changes after repeated transcranial direct current stimulation in rat stroke model[J]. J Korean Med Sci, 2010, 25(10):1499-1505.
[7] Belayev L, Alonso O F, Busto R, et al. Middle cerebral artery occlusion in the rat by intraluminal suture[J]. Stroke, 1996, 27(9):1616-1622.
[8] 卢旭霞, 牛小媛, 罗玉敏, 等.远程缺血后适应对大鼠脑缺血再灌注损伤的影响[J].中国脑血管病杂志, 2010, 7(3):139-142.
[9] 宋兆晶, 牛小媛, 吉训明, 等.远程缺血后适应对脑缺血损伤的实验研究[J].中国医学创新, 2010, 7(11):1-4.
[10] Ren C, Yan Z, Wei D. Limb remote ischemic postconditioning protects against focal ischemia in rats[J]. Brain Res, 2009, 1288(8):88-94.
[11] Kin H, Zhao Z Q, Sun H Y, et al. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion[J]. Cardiovasc Res, 2004, 62(1):74-85.
[12] 陈靖宜, 刘菊英.大鼠心肌缺血再灌注损伤模型的制备及改进[J].临床误诊误治, 2012, 25(2):14-16.

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