Mechanical responses of cochlear outer hair cells

doi:10.3969/j.issn.1006-7795.2014.04.019

Abstract

Abstract:

Objective To examine the influence of membrane conductances and mechanical load on the dynamic characteristics of outer hair cell(OHC) motility. Methods All the experiments were performed on OHCs isolated from the 4th turns of guinea pig cochleae, using whole-cell voltage-clamp and microchamber techniques. Motility was measured using a photodiode-based measurement system. Results Membrane conductances influence both sensitivity and nonlinearity of motility, and that mechanical load significantly affects magnitude, asymmetry and frequency response of motility. Conclusion Membrane conductances and mechanical load influence OHC motility, thereby, the cochlear amplifier.

Key words: outer hair cell, motility, mechanical load, frequency response, guinea pig

CLC Number:

R764.35

Li Yi, Liu Huizhan, Gong Shusheng, He Zhizhou. Mechanical responses of cochlear outer hair cells[J]. Journal of Capital Medical University, 2014, 35(4): 477-482.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.04.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I4/477

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