Five-month-old APP/PS1 double transgenic mice behavior and pathology of senile plaques

doi:10.3969/j.issn.1006-7795.2016.06.013

Abstract

Abstract: Objective To explore behavior related to learning and memory ability of 5-month-old APP/PS1 double transgenic mice and pathology in the brain. Methods Five-month-old APP/PS1(+/-) double transgenic mice were tested with Morris water maze. β-amyloid plaques were studied with immunohistochemical staining and Congo red staining to observe-amyloid plaques deposition. ResultsAPP/PS1(+) mice escape latency was significantly longer than that of APP/PS1(-) mice, 5-month-oldAPP/PS1(+) mice learning and memory ability were damaged. β-amyloid plaques immunohistochemical staining and Congo red staining showed senile plaques in 5-month-old APP/PS1(+) mice. Conclusion Five-month-old APP/PS1 (+) mice learning and memory ability were damaged, a part of Alzheimer disease pathology was shown in the brain of 5-month-old APP/PS1(+) mice.

Key words: APP/PS1 double transgenic mouse, β-amyloid plaques, Congo red stain

CLC Number:

R592

Chen Chen, Yang Cuicui, Li Lin, Zhang Lan. Five-month-old APP/PS1 double transgenic mice behavior and pathology of senile plaques[J]. Journal of Capital Medical University, 2016, 37(6): 784-788.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.06.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I6/784

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