Role of endoscopic ultrasound(EUS)-guided targeted biopsy in conventional endoscopic biopsy negative lesions

doi:10.3969/j.issn.1006-7795.2018.05.007

Journal of Capital Medical University ›› 2018, Vol. 39 ›› Issue (5): 657-662.doi: 10.3969/j.issn.1006-7795.2018.05.007

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Role of endoscopic ultrasound(EUS)-guided targeted biopsy in conventional endoscopic biopsy negative lesions

Hao Xiaowen, Sun Xiujing, Li Peng

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University;National Clinical Research Center for Digestive Diseases;Beijing Digestive Disease Center;Faculty of Gastroenterology, Capital Medical University;Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China

Received:2018-07-31 Online:2018-09-21 Published:2018-10-20
Supported by:
This study was supported by National Natural Science Foundation of China (81570507), National Key R&D Program of the Ministry of Science and Technology(2017YFC0113600), Beijing-Tianjin-Hebei Region Collaborative Innovation Promoting Project Founded by Beijing Science and Technology Commission (Z171100004517009), Clinical Research and Key Technology Upgrading Projects of Beijing Science and Technology Commission (Z161100001816033),Beijing Municipal Science & Technology Commission(Z141107002514018), Capital Health Research and Development of Special(2016-1-2022).

Abstract

Abstract: Objective To evaluate the efficacy and safety of endoscopic ultrasound (EUS)-guided biopsy in the diagnosis of underlying malignancy in patients with suspicious esophageal and gastric cancer and negative mucosal biopsies. Methods A retrospective analysis was conducted in sixteen patients who have suspicious esophageal and gastric cancer but endoscopic biopsy was negative. EUS and EUS-guided biopsy were performed to all those patients from May 2016 to July 2018 in our hospital. Results Sixteen patients (5 male) aged 29-83 years[median (53.19±16.98) years] were included in this study. Malignancy was confirmed in 8/16 patients on histology, suspicious tumor cells were found in 3/16 patients (2 of the three patients were finally diagnosed as malignant tumor). The remaining five patients were diagnosed with benign diseases. EUS-guided biopsy showed a sensitivity of 100%, specificity of 83.3%, positive predictive value (PPV) of 90.9%, negative predictive value (NPV) of 100% and accuracy of 93.8%. The consistency of EUS-guided biopsy and final diagnosis was great (Kappa=0.86).There were no immediate or late complications. Conclusion EUS-guided targeted biopsy is a helpful and safe procedure in the diagnosis of esophageal and gastric tumors with negative endoscopic biopsies.

Key words: endoscopic ultrasound(EUS), EUS-guided biopsy, negative mucosal biopsies

CLC Number:

R445

Hao Xiaowen, Sun Xiujing, Li Peng. Role of endoscopic ultrasound(EUS)-guided targeted biopsy in conventional endoscopic biopsy negative lesions[J]. Journal of Capital Medical University, 2018, 39(5): 657-662.

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Role of endoscopic ultrasound(EUS)-guided targeted biopsy in conventional endoscopic biopsy negative lesions

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