Psychosocial characteristics associated with relapse of bipolar disorder

doi:10.3969/j.issn.1006-7795.2023.04.016

Abstract

Abstract: Objective To explore the psychosocial characteristics affecting relapse of bipolar disorder (BD). Methods A total of 269 BD patients from the outpatient department of Beijing Anding Hospital Affiliated to Capital Medical University from August 2020 to January 2022 were selected and divided into group of mood episode and group of non-mood episode. The differences of basic information, clinical characteristics, medication compliance, affective temperament, social support, childhood trauma and five-pattern personality of the two groups were analyzed. Then logical regression and mediating effect were used to determine the risk factors related to BD recurrence and the mediating relationship of these factors. Results Cyclothymic temperament, irritable temperament and Taiyin personality were positively correlated with BD relapse, while objective social support was negatively correlated with BD relapse. There was a direct effect between objective social support and depression, with an effect value -0.08. Both Cyclothymic temperament and Taiyin personality had mediating effects between objective social support and depressive mood, with the mediating values -0.018 and -0.028, respectively, and the total indirect effect was -0.046. The total effect value between objective social support and depressive mood was -0.127, and the mediating effect accounted for 36.2% of the total effect. ConclusionsThe more objective social support BD patients received, the lower the level of depressive mood. Social psychological intervention based on personality and temperament may help to suppress the recurrence of BD caused by poor social support.

Key words: bipolar disorder, psychosocial characteristics, cyclic temperament, five-state personality, relapse

CLC Number:

R749.4

Yan Aiguo, Liu Xinzi, Yin Dongqing, Zhu Hong , Jia Hongxiao , Li Ziyan. Psychosocial characteristics associated with relapse of bipolar disorder[J]. Journal of Capital Medical University, 2023, 44(4): 602-608.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.04.016

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I4/602

References

［1］ Stubbs B, Vancampfort D, Solmi M, et al. How common is bipolar disorder in general primary care attendees? A systematic review and meta-analysis investigating prevalence determined according to structured clinical assessments［J］. Aust N Z J Psychiatry, 2016, 50(7): 631-639.
［2］ Radua J, Grunze H, Amann B L. Meta-analysis of the risk of subsequent mood episodes in bipolar disorder［J］. Psychother Psychosom, 2017, 86(2): 90-98.
［3］ Dargél A A, Volant S, Brietzke E, et al. Allostatic load, emotional hyper-reactivity, and functioning in individuals with bipolar disorder［J］. Bipolar Disord, 2020, 22(7): 711-721.
［4］ Díaz-Caneja C M, Morón-Nozaleda M G, Vicente-Moreno R P, et al. Temperament in child and adolescent offspring of patients with schizophrenia and bipolar disorder［J］. Eur Child Adolesc Psychiatry, 2018, 27(11): 1459-1471.
［5］ Kemner S M, Mesman E, Nolen W A, et al. The role of life events and psychological factors in the onset of first and recurrent mood episodes in bipolar offspring: results from the Dutch Bipolar Offspring Study［J］. Psychol Med, 2015, 45(12): 2571-2581.
［6］ Doucette S, Levy A, Flowerdew G, et al. Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study［J］. Early Interv Psychiatry, 2016, 10(5): 381-389.
［7］ Kelman J, Thacher A, Hossepian K, et al. Personality and pediatric bipolar disorder: toward personalizing psychosocial intervention［J］. J Affect Disord, 2020, 275: 311-318.
［8］ Larsson S, Aas M, Klungsøyr O, et al. Patterns of childhood adverse events are associated with clinical characteristics of bipolar disorder［J］. BMC Psychiatry, 2013, 13: 97.
［9］ Selous C, Kelly-Irving M, Maughan B, et al. Adverse childhood experiences and adult mood problems: evidence from a five-decade prospective birth cohort［J］. Psychol Med, 2020, 50(14): 2444-2451.
［10］美国精神医学学会. 精神障碍诊断与统计手册［M］. 张道龙, 译. 5版. 北京: 北京大学出版社, 2015: 120-161.
［11］苑成梅, 黄佳, 李则挚, 等. 情感气质自评量表简版中文版的信效度［J］. 中国心理卫生杂志, 2014, 28(2): 151-155.
［12］薛崇成, 杨秋莉. 五态性格测验表手册［M］. 北京: 中国中医研究院针灸所, 1988: 77-101.
［13］肖水源. 《社会支持评定量表》的理论基础与研究应用［J］. 临床精神医学杂志, 1994(2): 98-100.
［14］ He J Y, Zhong X, Gao Y D, et al. Psychometric properties of the Chinese version of the Childhood Trauma Questionnaire-Short Form (CTQ-SF) among undergraduates and depressive patients［J］. Child Abuse Negl, 2019, 91: 102-108.
［15］ Cohen A N, Hammen C, Henry R M, et al. Effects of stress and social support on recurrence in bipolar disorder［J］. J Affect Disord, 2004, 82(1): 143-147.
［16］ Shokrgozar S, Rouzbehan V, Zare R, et al. Evaluation of patient social support, caregiver burden, and their relationship with the course of the disease in patients with bipolar disorder［J］. Int J Soc Psychiatry, 2022, 68(8): 1815-1823.
［17］ Kraepelin E. Manic-depressive insanity and paranoia［M］. Edinburgh: E&S. Livingstone, 1921.
［18］ Akiskal H S, Akiskal K. Cyclothymic, hyperthymic, and depressive temperaments as subaffective variants of mood disorders［J］. Am Psychiatr Press Rev Psychiatry, 1992, 11: 43-62.
［19］ Salhofer-Polanyi S, Friedrich F, Löffler S, et al. Health-related quality of life in multiple sclerosis: temperament outweighs EDSS［J］. BMC Psychiatry, 2018, 18(1): 143.
［20］ Bieliński M, Lesiewska N, Bielińska J, et al. Affective temperament in inflammatory bowel diseases: another brick in the wall of differentiation［J］. PLoS One, 2018, 13(11): e0205606.
［21］李自艳, 刘鑫子, 杜渐, 等. 双相情感障碍的中医五态人格特征初探［J］. 首都医科大学学报, 2021, 42(3): 408-411.
［22］李自艳, 曹龑, 贾竑晓. 贾竑晓以养阴调阳法治疗双相情感障碍的临床经验［J］. 中华中医药杂志, 2019, 34(7): 3087-3090.
［23］ Kelman J, Thacher A, Hossepian K, et al. Personality and pediatric bipolar disorder: toward personalizing psychosocial intervention［J］. J Affect Disord, 2020, 275: 311-318.
［24］ Hessels C J, Laceulle O M, Van Aken M A G, et al. Differentiating BPD in adolescents with NSSI disorder: the role of adverse childhood experiences and current social relationships［J］. Borderline Personal Disord Emot Dysregul, 2018, 5: 20.
［25］ Zou R, Xu X, Hong X B, et al. Higher socioeconomic status predicts less risk of depression in adolescence: serial mediating roles of social support and optimism［J］. Front Psychol, 2020, 11: 1955.
［26］ Li Z Y, Liu X Z, Ma R, et al. Cyclothymic temperament, physical neglect, and earlier age of onset predict poor medication adherence in patients with bipolar disorder［J］. J Nerv Ment Dis, 2023, 211(1): 35-39.
［27］ Quidé Y, Tozzi L, Corcoran M, et al. The impact of childhood trauma on developing bipolar disorder: current understanding and ensuring continued progress［J］. Neuropsychiatr Dis Treat, 2020, 16: 3095-3115.
［28］ Jaworska-Andryszewska P, Rybakowski J K. Childhood trauma in mood disorders: neurobiological mechanisms and implications for treatment［J］. Pharmacol Rep, 2019, 71(1): 112-120.
［29］ Larsson S, Aas M, Klungsøyr O, et al. Patterns of childhood adverse events are associated with clinical characteristics of bipolar disorder［J］. BMC Psychiatry, 2013, 13: 97.
［30］ Selous C, Kelly-Irving M, Maughan B, et al. Adverse childhood experiences and adult mood problems: evidence from a five-decade prospective birth cohort［J］. Psychol Med, 2020, 50(14): 2444-2451.

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