Initial Study on the Association between Diabetes and HLA

Abstract

Abstract: HLA typing in 29 cases of diabetes patients were perfomed, and then those were com-pared with the HLA typing results in 59 cases of health individuals. The antigen friquencies were distinctly rose in DRw12, Cw9, DRw17, Bw75, A3, DR9, A2, DQw2, B35, DQw9, DRw53, Cw6 and DR7 etc, compared with normal individuals as control group. The antigen friquencies of Cw7, Cw1, B39, DR4, DRw16, A26, DR1, DQw5, DQw8 and DQw6 etc, dis-tinctly reduced. The haplotype A2-B13, DRw12-DQw7 and B35-Cw9 had significant linkage disequilibrium. The linkage disequilibrium parameters were of positive numbers, they showed orthodromic links; but the linkage disequilibrium parameters of Cw10-DQw6, Cw6-DRw12, Cw10-DRw15, B35-Cw10, A2-B35, Cw4-DQw9, Cw4-DR9, B60-Cw9, DRw12-DQw2, A24-Cw6 and A3-B13, were negative, they showed minus links, those prompt to what they could be specific haplotypes with protective sense.

Key words: diabetes, HLA antigen, haplotype, association

CLC Number:

R587.1

Er Xiujiang;Li Zhexian;Bi Rumei;Xu Xiuhong;Jia Baoxiang;Liu Hong. Initial Study on the Association between Diabetes and HLA[J]. Journal of Capital Medical University, 1992, 13(2): 117-123.

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Initial Study on the Association between Diabetes and HLA

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