Abstract: We conducted a random crossover study on the effects of a new androgenic preparation “andriol”in 62 elderly men with coronary heart disease(CHD).Our results showed that serum estradial(E₂)level and estradial/testosterone(E₂/T)ratio were significantly elevated and serum T level was significantly reduced(all P<0.001)in CHD patients,when com-pared with those in healthy controls,indicating that there was disorder of sex hormones (SH)in elderly men with CHD.After administration of andriol,the disorder of SH in CHD patients was improved,that is,serum T level was increased significantly(P<0.001),E₂ le-vel did not change significantly(P>0.05)and E₂/T ratio was reduced(P<0.05).There was no significant change in the control group.No obvious side effect was found in those who took andriol.

Key words: coronary heart disease, testosterone, estradial