Abstract: Experiments were conducted on Kunming mice. Potassium cyanide(CN), lodo-acetic acid(IA), malonic acid(MA),and CN plus IA were used to block the respiratory chain, glycosis,tricarboxylic acid cycle(TAC)and respiratory chain plus glycosis, respectively. The animal's survival time following the four types of treatment was compared. The survival time of experimental group(A)which went through three times of exposure to hypoxia was 3.83(CN), 25.31(IA), 12.27(MA), and 1.83(IA MCN)min, respectively. The survival time of the control mice(B)which weren't exposured to hypoxia was 1.45(CN),6.57(IA), 9.07(MA),and 0.65(CN±IA)min, respectively. The survival time for normal and three exposure to hypoxia in another control group(C)which were injected with no drugs but normal saline(NS)was 13.28 and 40.53min,respectively. The survival time in group A and B was significantly shorter than that in group C, but the survival time in group A was all significantly longer than that in group B. These results suggest that the ability of respiratory chain, TAC,and glycosis can be increased by the procedure of repetitve exposure to acute hypoxia. In addition,there might be an adaptation to hypoxia at tissue level and independent of energy metabolism.

Key words: aerobic oxidation, glycosis, hypoxia, mouse