Abstract: 74 subjects,aged 14～76 years,with heart rate range 55～104 bpm with no evidence of cardiovascular disease were included in this study. To determine the normal range of pulsed Doppler measurements of left ventricular filling multiple regression was used to analyse the effects of age and heart rate on the measurements. The regression equation was used to calculate the predicted normal values adjusted by age and heart rate within 95% confidence interval (95% CI) and the age,heart rate predicted value table was made. The peak atrial filling velocity (A) and peak early filling velocity/peak atrial filling velocity (E/A) were significantly correlated with heart rate and age (R=0.66, 0.65P <0.001) .With every 10 years increase in age,an increase in 5.9 (95% CI 5.0～6.8)cm/s,E/Adecrease in 0.21 (0.18～0.24) and with every 5 beats increase in heart rate an increase in 2.33 ( 1.80～2.85 )cm/s and E/Adecrease in 0.06 ( 0.03～0.09 ) were found. With predicted values,changes of diastolic function could be assessed.

Key words: diastolic function, Doppler echocardiography, age, heart rate