The Effect of Diabetes on Ischemia/ Reperfusion Ventricular Fibrillation and Ischemic Preconditioning in Rats

Journal of Capital Medical University ›› 1998, Vol. 19 ›› Issue (4): 312-314.

• 论著 • Previous Articles Next Articles

The Effect of Diabetes on Ischemia/ Reperfusion Ventricular Fibrillation and Ischemic Preconditioning in Rats

Zhang Like¹, Zhu Yingfen¹, Lu Lingqiao¹, Lou Shugang¹, Wang Wen¹, Ding Dingwu¹, Fu Ping², Xie Ruoxiang³

1. Department of Pathophysiology, Capital University of Medical Sciences;2. Institute of Natrition, Chinese Academy of Medical Science;3. Beijing Children's Hospital Affiliate of Capital University of Medical Sciences

Received:1997-10-15 Revised:1900-01-01 Online:1998-10-15 Published:1998-10-15

Abstract

Abstract: The alloxan diabetes rat model was used to study the effect of diabetes on ischemia/reperfusion ventricular fibrillation rate(VFr), times(VFt)and ischemic preconditioning. The results showed that the reperfusion VFr in diabetes rats were less than that in normal rats(P<0.05), and the ischemia and reperfusion VFt in diabetes rats were shorter than that in normal rats. It suggested that there was the better cardiac electricity stability in early diabetes rats. The ischemic precondation did not changed the reperfusion VFt and VFr, but increased the ischemic VFt. It indicated that the self protect function of the diabetes heart was decreased.

Key words: diabetes, ischemia/reperfusion injury, ischemic preconditioning, ventricular fibrillation

CLC Number:

R587.1

Zhang Like;Zhu Yingfen;Lu Lingqiao;Lou Shugang;Wang Wen;Ding Dingwu;Fu Ping;Xie Ruoxiang. The Effect of Diabetes on Ischemia/ Reperfusion Ventricular Fibrillation and Ischemic Preconditioning in Rats[J]. Journal of Capital Medical University, 1998, 19(4): 312-314.

[1]	Zhao Yue, Ruan Xiangyan, Zou Liying, Ma Jun, Wang Yuejiao, Tian Xuanxuan, Jin Jing. Correlation between thyroid autoimmunity and gestational diabetes mellitus in Chinese euthyroid women [J]. Journal of Capital Medical University, 2025, 46(4): 626-631.
[2]	Bai Jing, Qin Yichuan, Liu Yu, Liu Xiangyi. Clinical application of adiponectin in gestational diabetes mellitus and the establishment of an early risk model [J]. Journal of Capital Medical University, 2025, 46(3): 567-575.
[3]	Li Qian, Zhu Hong, Ye Meng, Wu Yanzhe , Wu Li, Ma Weiwei. The correlation between phase angle and sarcopenia in middle-aged and elderly patients with type 2 diabetes mellitus [J]. Journal of Capital Medical University, 2025, 46(2): 340-347.
[4]	An Qi, Yang Nan, Zhu Yuequan, Shi Wenjuan, Huang Minqi, Zhao Yongmei. Effect of autophagy inhibitor 3-MA on inflammatory response in the brain of rats with cerebral ischemia/reperfusion injury [J]. Journal of Capital Medical University, 2024, 45(6): 1008-1015.
[5]	Li Xingmao, Li Xiu, Wang Ting, Zhao Xin, Wang Deyang, Shang Haiyan, Zhao Yongmei, Li Sen. Effects of GLP-1 receptor agonists on cognitive function in patients with type 2 diabetes mellitus after acute ischemic stroke [J]. Journal of Capital Medical University, 2024, 45(6): 1029-1037.
[6]	Zhu Yingna, Li Xiaohui, Yuan Mingxia. Effect of monocyte/high density lipoprotein-cholesterol ratio combined with body mass index in evaluating insulin resistance [J]. Journal of Capital Medical University, 2024, 45(6): 1079-1087.
[7]	Li Xiaojing, Liu Hongzhou, Dong Song, Wang Hong. Association between plasma trimethylamine-N-oxide level and type 2 diabetes mellitus [J]. Journal of Capital Medical University, 2024, 45(6): 1100-1105.
[8]	Wang Tianyuan, Yu Yun, Han Ruquan. Advances in clinical application and perioperative studies of glucagon-like peptide-1 receptor agonists [J]. Journal of Capital Medical University, 2024, 45(6): 1115-1121.
[9]	Liu Chang, Xin Zhong, Yang Jinkui. Relationship between diet quality scores and all-cause mortality in diabetic patients of different genders [J]. Journal of Capital Medical University, 2024, 45(3): 406-412.
[10]	Gao Xia, Hu Yanjin, Yao Zhi, Wang Guang. The correlation between vascular endothelial function and thyroid hormone sensitivity in newly diagnosed type 2 diabetes patients [J]. Journal of Capital Medical University, 2024, 45(3): 413-419.
[11]	Zheng Xiaomin, Liu Mengyang, Xiao Xinhua, Cui Limei, Liu Cuiping. Effects of vitamin D₂ on albuminuria in patients with diabetic kidney disease [J]. Journal of Capital Medical University, 2024, 45(3): 420-428.
[12]	Zhang Lin, Xie Rongrong, Yang Fangyuan, Li Mei, Luo Sha, Wan Xiaohua, Tian Wei, Yang Jinkui. Diagnostic value of renal tubular and glomerular markers in different stages of renal injury in patients with type 2 diabetes [J]. Journal of Capital Medical University, 2024, 45(3): 429-437.
[13]	Zhu Lin, Xu Yongsong, Feng Xiaotong, Zhao Dong, Ke Jing. Progresses in the drug treatment of diabetic retinopathy [J]. Journal of Capital Medical University, 2024, 45(3): 438-445.
[14]	Hu Yafen, Hua Lin. The causal relationship between intestinal flora and diabetes, inflammatory factors and C-reactive protein: Mendelian randomized analysis [J]. Journal of Capital Medical University, 2024, 45(3): 488-493.
[15]	Gao Yanyan, Ren Xiuwen, Wang Xixiang, Xu Jingjing, Ma Xiaojun, Liu Lu, Liu Yu, Yuan Linhong. Correlation between serum vitamin A and vitamin E and cognitive function in aging subjects with type 2 diabetes mellitus [J]. Journal of Capital Medical University, 2023, 44(6): 1060-1066.

The Effect of Diabetes on Ischemia/ Reperfusion Ventricular Fibrillation and Ischemic Preconditioning in Rats

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments