The Therapeutic Effects of Nicotinic Acid on the Lung Injury in Acute Necrotizing Pancreatitis in Rats

Abstract

Abstract: A model of lung injury following acute necrotizing pancreatitis in rats was produced by inje cting sodium taurocholate under the pancreatic coating. The changes of TXB₂/6-keto-PGF_1α in plasma was observed by radioimmunoassay. The effects of nicotinic acid on lung injury following acute necrotizing pancreatitis was studied. The results showed that TXB₂,TXB₂/6-keto-PGF_1α and lung index of acute necrotizing pancreatitis in rats were elevated progressively. Nicotinic acid caused a marked decrease in both the level of TXB₂, ratio of TXB₂/6-keto-PGF_1α and the lung index. The data indicated that the changes of TXB₂,6-keto-PGF_1α balance may be one of methanisms responsible for plumonary injury caused by acute necrotizing pancreatitis. Necotinic acid may has a therapeutic effect on acute necrotizing pancreatitis associated lung injury.

Key words: pancreatitis, lung, prostaglandins, thomboxane B₂, nicotinic acid

CLC Number:

R576
R563

Gu Junchao;Wang Yu;Qin Zhaoyin. The Therapeutic Effects of Nicotinic Acid on the Lung Injury in Acute Necrotizing Pancreatitis in Rats[J]. Journal of Capital Medical University, 1998, 19(4): 349-351.

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The Therapeutic Effects of Nicotinic Acid on the Lung Injury in Acute Necrotizing Pancreatitis in Rats

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