Protecting Effects of Baicalin on Isoprenaline-induced Myocardial Injury in Rats

Journal of Capital Medical University ›› 1999, Vol. 20 ›› Issue (2): 86-88.

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Protecting Effects of Baicalin on Isoprenaline-induced Myocardial Injury in Rats

Hei Ailian¹, Xu Pingxiang¹, Sun Songsan¹, Duan Chunli², Hu Xiaomin¹

1. Department of Pharmacology, Capital University of Medical Sciences;2. Department of Institute Neurosciences, Capital University of Medical Sciences

Received:1998-07-20 Revised:1900-01-01 Online:1999-04-15 Published:1999-04-15

Abstract

Abstract: Protective effects of baicalin on acute myocardial injury induced by isoprenaline were studied in rat. Animals were seperated into four groups of control、 myocardial ischemia model、 baicalin Ⅰ and baicalin Ⅱ. The effects of baicalin on electro cardiogram,serum CPK and myocardial malonialdehyde (MDA) and superoxide dismutase (SOD) were observed in rats. The results showed that baicalin inhibited the raising of ST period,depressed the release of CPK,reduced myocardial MDA production,protected myocardial SOD activity in the isoprenaline-induced damege of rat heart. The results suggested that baicalin possessed protective effects on ischemic myocardium and the action was considered to be related to the inhibition of lipid peroxidation.

Key words: baicalin, isoprenaline, myocardial injury, superoxide dismutase, lipid peroxides

CLC Number:

R932.5

Hei Ailian;Xu Pingxiang;Sun Songsan;Duan Chunli;Hu Xiaomin. Protecting Effects of Baicalin on Isoprenaline-induced Myocardial Injury in Rats[J]. Journal of Capital Medical University, 1999, 20(2): 86-88.

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Protecting Effects of Baicalin on Isoprenaline-induced Myocardial Injury in Rats

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