Abstract: 150 patients with pituitary adenoma (84 PRL secreting pituitary adenomas, 30 GH-secreting pituitary adenomas and 36 nonfunctioning pituitary adenomas) were treated by adnomectomy. The dynamic studies of serum PRL, GH, Cortisol, ACTH and thyroidal functions (T₃, T₄, TSH) were performed before and after microsurgery. PRL and GH levels decreased strikingly within one week after treatment and didnt change afterwards. It was concluded that PRLand GHlevels could be one of the major indicators to judge the effect of surgery. Serum T₃ also decreased significantly and the other pituitary hormones had no significant changes. It suggested that adenomectomy could cause the serum T₃ decreased.

Key words: pituitary adenoma, pituitary hormone, microsurgery