Abstract: To evaluate the importance of different risk factors and their mutual interactions on glomerular filtration rat(GFR)in type 2 diabetes mellitus, an investigation was carried out on the relationship between GFR and various risk factors in 214 cases of type 2 diabetes by way of stepwise regression analysis method. Results: ① The average age, DM course, waist/hip-ratio, hypertension prevalence, coronary heart disease prevalence and diabetic retinopathy prevalence were higher in GFR dropped group than that of GFR normal group(P<0.01). ② The values of GFR, BUN, Scr, UAER were significant difference between two groups(P<0.01). ③ Multiple backward regression analysis showed that age, Scr, diabetic retinopathy, hypertension and BUN were independent risk factors for GFR. Conclusion: To dealy the decrease of GFR and prevent the occurrence of diabetic nephropathy, it is important not only to control blood sugar, but also to control blood pressure and relieve diabetic retinopathy.

Key words: type 2 diabetes mellitus, glomerular filtration rate, multiple factor analysis