Effects of BDNF and NT-3 on Growth and Development of Fetal Rats′Spinal Cord Neurons

Journal of Capital Medical University ›› 2002, Vol. 23 ›› Issue (3): 202-205.

• 基础研究 • Previous Articles Next Articles

Effects of BDNF and NT-3 on Growth and Development of Fetal Rats′Spinal Cord Neurons

Liu Limin¹, Huang Haixia¹, Gao Jianxin ²

1. Department of Physiology, Capital University of Medical SciencesDepartment of Physiology, Medical School of Shandong University;2. Department of Physiology, Medical School of Shandong University

Received:2001-12-30 Revised:1900-01-01 Online:2002-07-15 Published:2002-07-15

Abstract

Abstract: The objective was to study the effects of brain-derived neurotrophic factor(BDNF)and neurotrophin-3(NT-3)on the growth and development of cultured spinal cord neurons of fetal rats. The survival and growth condition of cultured spinal cord neurons were observed under phase-contract microscope. The cell numbers were counted. The body diameter and process were measured. All data obtained were expressed by x±s and analyzed by variance analysis and SNK test. Both BDNF and NT-3 can increase survival rate of neurons in vitro. Effect of BDNF is more significant than NT-3. BDNF can enhance the development of cell bodies and NT-3 can promote the outgrowth of processes. BDNF and NT-3 have specific effects on growth and development of cultured spinal cord neurons.

Key words: BDNF, NT-3, spinal cord, neurons, embryonic rat

CLC Number:

R338.2⁺1

Liu Limin;Huang Haixia;Gao Jianxin . Effects of BDNF and NT-3 on Growth and Development of Fetal Rats′Spinal Cord Neurons[J]. Journal of Capital Medical University, 2002, 23(3): 202-205.

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Effects of BDNF and NT-3 on Growth and Development of Fetal Rats′Spinal Cord Neurons

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