Abstract: The aim was to investigate clinical characteristic of the Dieulafoy lesion and causation of gastrointestinal bleeding and.Patients were divided into 2 groups according to initial endoscopic treatment method.Thirty-seven cases of Dieulafoy lesion were endoscopic injection groups.Forty cases of upper GI bleeding from a peptic ulcer were control groups.Data were analyzed with respect to clinical and endoscopic characteristics as well as outcome.Endoscopic injection therapy was successful in 36 patients(97.3%).One patient had successful surgery after endoscopic therapy failed.Most patients with Dieulafoy lesion were elderly men 〔average (61.14±9.18) years〕 with severe acute upper gastrointestinal hemorrhage.There were significant differences between the 2 groups with respect to age ( P<0.01), hemorrhage values (P<0.01), localization of lesion ( P< 0.01), number of therapeutic endoscopic sessions (P<0.01), delitescent time (P<0.01), and number of units transfused (P< 0.01).There were no deaths due to bleeding and no endoscopic complications.Dieulafoy lesion occurs most frequently in elderly males with severe acute upper bleed gastroiatestinal hemorrhage.Many patients in this series (81.1%) had significant comorbidity, in particular, cardiovascular disease, hypertension, and diabetes.Endoscopic injection therapy of Dieulafoy lesion is safe, economical, effective, successful, and should be performed.There are no deaths due to bleeding and no endoscopic complications.

Key words: Dieulafoy lesion, endoscopy, treatment, clinical characteristic