Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (4): 427-430.

• 论著·基础研究 • Previous Articles     Next Articles

Simultaneous Evaluation of Effect of Rhizoma Curcumae Longae on Hepatic CYP450 by Cocktail Probe Drugs

Hu Jinping, Yan Shulian, Tang Jingcheng, Zhang Jinnan   

  1. Department of Chemical Pharmacology, Capital University of Medical Sciences
  • Received:2003-08-20 Revised:1900-01-01 Online:2004-10-15 Published:2004-10-15

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Abstract: The aim was to study the change of the rat hepatic CYP 450 content following administration of Rhizoma Curcumae Longae by cocktail probe drugs. Rats were randomly divided into groups. One group of rats received Rhizoma Curcumae Longae plant extracts once daily orally for six days. The rats in another group received once daily orally normal saline as blank control group and phenobarbital as positive control group at the same time. The plasma concentration of cocktail probe drugs was determined by HPLC. The CYP1A2 and CYP2E1 content of the groups of rats received Rhizoma Curcumae Longae plant extracts was reduced, but the CYP3A4 content didn't markedly change. It suggests that Rhizoma Curcumae Longae is inhibitor of the CYP1A2 and CYP2E1, but the CYP3A4 can be hardly affected.

Key words: Cocktail, CYP450, caffeine, dapsone, chlorzoxazone, probe drugs, Rhizoma Curcumae Longae

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