Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (4): 446-449.

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The Correlation between Uterine Bleeding Induced by Intrauterine Device and Angiogenesis

Zhang Hua1, Sun Haimei1, Zhou Qi2, Xie Feng2, Li Baohong1   

  1. 1. Department of Histology and Embryology, Capital University of Medical Sciences;2. Department of Obstetries and Gyneclogy, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences
  • Received:2003-09-19 Revised:1900-01-01 Online:2004-10-15 Published:2004-10-15

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Abstract:

The aim was to investigate the effects of vascular endothelial growth factor(VEGF) and kinase insert domaincontaining receptor(KDR) in uterine bleeding induced by intrauterine device(IUD). Immunohistochemical method was used to detect the expressions of VEGF and KDR in endometrium from IUD bleeding group and normal control group. Microvessel density (MVD) was evaluated by using anti factor Ⅷ-related antigen (F8-RA) antibody to mark stromal microvessels. The expressions of VEGF and KDR were significantly higher in endometrium of IUD bleeding group than those of control group (P<0.001). MVD was significantly higher in IUD bleeding endometrium than that in normal endometrium (P<0.001). The increase of VEGF and KDR contents result in the increase of MVD, which may be related to abnormal bleeding in IUD users.

Key words: IUD, VEGF, KDR, MVD

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